Fig. 4.

B. wadsworthia regulates expression of inflammatory and metabolic-related host genes under HFD setting. a Fold change of B. wadsworthia (Bw) relative from altered Schaedler flora (ASF)-colonized mice fed with control diet (CD). b Left: Bubble plot of -log10(BH p-values) of a selection of significant pathway activities between indicated groups (Blue: up regulated in first compared to second group. Red: down regulated in first compared to second group); right: Heatmap of corresponding pathway activity. c Cytokine production in caecum, mesenteric lymph node and spleen (*p < 0.05 vs. HFD-ASF, ⁺p < 0.05 vs. HFD-ASF^Bw+; n = 4–5/group). Statistical comparison was performed by first testing normality using Kolmogorov–Smirnov test and then ANOVA or Kruskal–Wallis test with Bonferroni or Dunn’s post hoc test. Error bars represents SEM