Figure 1.

Replica molding and micro-pattern characterization. (a) SEM micrograph of elastomeric microstructured substrate manufactured using soft-lithography and coated with fibronectin. Scale bar: 10 µm. Inset, scale bar: 5 µm. (b) Layout of the patterns on the elastomeric microstructured substrate for cell adhesion experiments. (c) Elemental cells of the investigated patterns for cell adhesion reduction. Parametric design space for elastomeric microstructured substrate in the (d) hexagonal and (e) squared patterns considering manufacturing constraints and rationale mechanobiological design principles.