Table 6.
Inhibitory activity of pure caffeoylquinic acids (CQA) against α-amylase and α-glucosidase (IC50, μM).
| Substance | Inhibitory activity against enzyme as IC50 | |
|---|---|---|
| α-Amylase (μM) | α-Glucosidase (μM) | |
| 1-O-CQA* | 172.47 ± 5.34h | 1240.35 ± 42.10f |
| 3-O-CQA | 169.50 ± 4.41h | 1209.63 ± 41.12f |
| 4-O-CQA | 109.59 ± 3.39g | 1028.32 ± 40.01ef |
| 5-O-CQA | 84.92 ± 2.37ef | 713.88 ± 19.98cd |
| 1,3-Di-O-CQA | 100.67 ± 2.81fg | 983.53 ± 28.52de |
| 1,5-Di-O-CQA | 77.43 ± 2.24de | 753.92 ± 23.37c |
| 3,4-Di-O-CQA | 67.17 ± 2.01cd | 209.72 ± 6.50b |
| 3,5-Di-O-CQA | 51.29 ± 1.64bc | 184.34 ± 5.34b |
| 4,5-Di-O-CQA | 42.32 ± 1.18ab | 62.14 ± 1.49a |
| 3,4,5-Tri-O-CQA* | 40.57 ± 1.05a | 61.08 ± 1.77a |
| Acarbose | 482.54 ± 15.44i | 1875.33 ± 60.01g |
Substances marked with asterisks (*) were not detected in Artemisia species studied. Mean values ± standard deviations. Statistical analysis was performed by one-way ANOVA (Tukey test). In each column, different letters (a–g) stand for significant statistical different data (p < 0.05).