Table 2.
Hemodynamics and oxygen derived parameters.
| Variable | Group | BL1 | Injury | BL2 | Time 1 | Time 2 | Time 3 | Time 4 | Time 5 | Time 6 | Group effect |
|---|---|---|---|---|---|---|---|---|---|---|---|
| (%) | |||||||||||
| VCV | 11.8 ± 5.2 | 58.1 ± 09 | 44 ± 22 | 27.9 ± 15 | 20.1 ± 08 | 18 ± 7.5 | 25 ± 25 | 16 ± 5.7 | 15 ± 5.4 | ||
| WN | 10.8 ± 5.3 | 59.8 ± 16 | 45 ± 16 | 23.5 ± 12 | 24.5 ± 20 | 15 ± 5.7 | 13 ± 4.0 | 12 ± 4.7 | 12 ± 6.1 | ||
| P04 | 11.9 ± 4.6 | 57.7 ± 13 | 44 ± 12 | 19.6 ± 6.2 | 14.5 ± 4.5 | 12 ± 3.5 | 12 ± 5.5 | 12 ± 6.1 | 12 ± 6.3 | ||
| P10 | 13.0 ± 4.4 | 51.8 ± 15 | 37 ± 11 | 16.8 ± 3.6 | 14.0 ± 3.3 | 12 ± 2.7 | 11 ± 3.1 | 10 ± 5.0 | 09 ± 4.4 | ||
| CO (L/min) | |||||||||||
| VCV | 4.6 ± 1 | 5.4 ± 2.1 | 4.9 ± 2.1 | 4.2 ± 1.4 | 3.7 ± 0.9 | 3.5 ± 0.7 | 3.6 ± 0.8 | 3.6 ± 0.8 | 3.5 ± 0.8 | ||
| WN | 5.0 ± 1.0 | 6.1 ± 1.6 | 5.1 ± 1.4 | 4.3 ± 0.7 | 3.9 ± 0.6 | 3.8 ± 0.6 | 3.9 ± 0.6 | 3.9 ± 0.5 | 3.9 ± 0.6 | ||
| P04 | 5.3 ± 1.2 | 5.8 ± 1.7 | 5.3 ± 1.1 | 4.1 ± 1.1 | 3.7 ± 0.8 | 3.5 ± 0.6 | 3.5 ± 0.7 | 3.6 ± 0.8 | 3.5 ± 0.8 | ||
| P10 | 4.7 ± 1.1 | 4.6 ± 0.7 | 4.4 ± 0.9 | 3.8 ± 0.8 | 3.6 ± 0.8 | 3.7 ± 0.7 | 3.4 ± 0.8 | 3.4 ± 0.8 | 3.4 ± 0.9 | ||
| HR (min−1) | |||||||||||
| VCV | 97.5 ± 14 | 101 ± 14 | 96.0 ± 15 | 88.0 ± 12 | 83.2 ± 9 | 82.4 ± 10 | 79.1 ± 11 | 78.0 ± 10 | 79.5 ± 11.0 | ||
| WN | 94.1 ± 12 | 103 ± 15 | 93.4 ± 12 | 83.2 ± 12 | 82.1 ± 12 | 78.8 ± 10 | 77.0 ± 8 | 76.0 ± 6.6 | 73.2 ± 7.5 | ||
| P04 | 92.8 ± 7.6 | 105 ± 19 | 98.1 ± 9.9 | 83.5 ± 7.8 | 80.7 ± 5.5 | 78.3 ± 3.4 | 75.7 ± 4.8 | 74.5 ± 5.9 | 72.2 ± 6.7 | ||
| P10 | 101 ± 12 | 95.5 ± 15 | 92.0 ± 13 | 85.3 ± 10 | 83.6 ± 13 | 80.6 ± 14 | 77.3 ± 16 | 75.9 ± 16 | 76.8 ± 17 | ||
| MAP (mm Hg) | |||||||||||
| VCV | 72 ± 11 | 89 ± 10 | 89 ± 14 | 90 ± 12 | 88 ± 10 | 86 ± 09 | 85 ± 09 | 82 ± 08 | 80 ± 09 | ||
| WN | 76 ± 09 | 89 ± 19 | 88 ± 11 | 87 ± 08 | 93 ± 11 | 87 ± 12 | 85 ± 12 | 81 ± 12 | 79 ± 09 | ||
| P04 | 74 ± 13 | 92 ± 12 | 92 ± 11 | 91 ± 11 | 88 ± 10 | 88 ± 07 | 85 ± 10 | 83 ± 09 | 79 ± 07 | ||
| P10 | 83 ± 13 | 94 ± 13 | 91 ± 13 | 89 ± 11 | 87 ± 09 | 86 ± 09 | 82 ± 10 | 79 ± 09 | 80 ± 13 | ||
| MPAP (mm Hg) | |||||||||||
| VCV | 16.7 ± 1.6 | 32 ± 4.5.0 | 30.4 ± 3.7 | 29.2 ± 4.5 | 28.9 ± 4.1 | 31.0 ± 5.4 | 27.4 ± 4.3 | 27.0 ± 3.8 | 25.1 ± 4.0 | ||
| WN | 22.0 ± 19.0 | 33.9 ± 5.0 | 30.7 ± 5.5 | 28.3 ± 4.3 | 27.9 ± 3.7 | 28.1 ± 2.9 | 28.1 ± 2.6 | 27.0 ± 2.7 | 26.4 ± 2.7 | ||
| P04 | 17.4 ± 4.6 | 32.2 ± 5.9 | 31.7 ± 4.9 | 26.7 ± 4.0 | 27.2 ± 3.9 | 27.4 ± 4.2 | 27.3 ± 4.6 | 27.2 ± 4.2 | 26.3 ± 3.8 | ||
| P10 | 19.3 ± 3.3 | 33.6 ± 3.5 | 30.3 ± 4.3 | 27.6 ± 4.7 | 27.1 ± 5.2 | 27.0 ± 4.8 | 25.1 ± 4.5 | 24.3 ± 4.8 | 25.0 ± 4.5 | ||
Ratio of partial arterial oxygen pressure to fraction of inspired oxygen (P/F Ratio); intrapulmonary shunt (); partial arterial pressure of carbon dioxide (PaCO2); cardiac output (CO); heart rate (HR); mean arterial blood pressure (MABP); mean pulmonary arterial blood pressure (MPAP); conventional volume controlled ventilation (VCV); variable volume controlled ventilation with Gaussian white noise pattern in tidal volume (WN); variable volume controlled ventilation with periodicity of 4 cycles (P04) and variable volume controlled ventilation with periodicity of 10 cycles (P10). Values are shown as mean and standard deviation, and were obtained from 40 animals in total (n = 10/group). There were no missing values. Statistical significance was accepted at P < 0.05. Comparability of groups at Injury and BL2 was tested using one-way ANOVA followed by Bonferroni post-hoc tests. Differences among groups (group main effect) were tested with general linear model statistics using values at BL2 as covariate and adjusted for repeated measurements according to the Sidak procedure.