Table 4.

Diffuse alveolar damage.

Feature	group	Ventral region	group effect	Dorsal region	Group effect
Alveolar edema	VCV	2[0–4]	n.s.	1[0–2]	n.s.
	WN	4[1–6]		1[0–4]
	P04	1[0–8]		2[0–4]
	P10	2[0–6]		1[1–3]
Intersitial edema	VCV	1[1–4]	n.s.	1[0–4]	n.s.
	WN	2[1–4]		1[1–3]
	P04	1[1–4]		1[1–2]
	P10	2[1–4]		1[1–4]
Hemorrhage	VCV	1[0–3]	n.s.	1[0–1]	n.s.
	WN	2[1–4]		1[0–2]
	P04	1[0–4]		2[0–3]
	P10	2[0–6]		1[0–3]
Inflammatory infiltration	VCV	8[3–12]	n.s.	3[1–6]	n.s.
	WN	12[5–15]		3[2–6]
	P04	6[2–12]		5[2–8]
	P10	8[1–12]		3[1–8]
Epithelial destruction	VCV	4[1–4]	n.s.	1[0–4]	n.s.
	WN	3[1–6]		1[1–6]
	P04	1[0–6]		2[1–9]
	P10	1[1–8]		4[1–9]
Microatelectasis	VCV	4[1–4]	n.s.	1[1–4]	n.s.
	WN	2[1–4]		1[1–2]
	P04	2[1–4]		2[1–4]
	P10	2[1–4}		1[1–2]
Overdistension	VCV	3[1–6]	n.s.	1[0–3]	n.s.
	WN	4[1–8]		1[0–2]
	P04	5[0–8]		2[0–3]
	P10	6[4–7]		1[0–3]
Cumulative score	VCV	26[13–33]	n.s.	12[3–20]	n.s.
	WN	33[18–43]		13[7–17]
	P04	21[5–48]		18[8–27]
	P10	26[9–45]		14[6–25]

Diffuse alveolar damage in ventral and dorsal lung regions. Conventional volume controlled ventilation (VCV); variable volume controlled ventilation with Gaussian white noise pattern (WN); variable volume controlled ventilation with periodicity of 4 cycles (P₀₄) and variable volume controlled ventilation with periodicity of 10 cycles (P₁₀). Values are shown as median and interquartile range, and were obtained from 40 animals in total (n = 10/group). There were no missing values. Differences among groups were tested with Kruskal-Wallis test followed by Mann-Whitney U-test and Bonferroni-Holm adjustments for pairwise comparisons. n.s (non-significant at P < 0.05).