Figure 2.

Interactions between the PKG Iα C-domain and N46. A, detailed interactions with N46. Only the regions near the active site are shown. N46 is shown with a transparent surface. Residues contacting N46 are shown as sticks. Water molecules are shown as blue spheres. B, enlarged views for each ring of N46, highlighting its interactions with different regions of the active site. Residues that provide VDW interactions are shown with transparent surfaces. Hydrogen bonds are shown as dotted lines, and arrows indicate key VWD interactions, with distances indicated in angstroms.