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R476A mutation of TLS exhibits limited inhibitory function on CCND1-driven promoter. A, luciferase reporter assays for CCNB1 and CCND1 promoter activity in HeLa cells. B, HeLa cells were cotransfected with CCND1 promoter and Renilla control vectors, along with expression vector for TLS or TLS mutants (R476A and R481A). The transcriptional activity was determined by the ratio of the relative luciferase activity. Data are presented in a box plot. n = 3. *, p < 0.01.
