Figure 8.

Cartoon of a model of VDAC pore blockage by the α-CTT or β-CTT of tubulin. The orientation of membrane-bound tubulin dimer is adopted from Ref. 39 with α-tubulin as the membrane-bound subunit. In such alignment, the contribution of the length and especially the first amino acids of the CTT to the blocking kinetics should be different for α-CTTs (a) and β-CTTs (b). There is some degree of rotational dynamics for the stably bound α-tubulin shown in (b) with the arrow and shadow image, which could also affect the kinetics of pore blockage by the β-CTT.