Table 1.
U1-70K protein–protein interaction network generates modules enriched with specific gene ontology (GO) terms
| Module color | Ontology type | Top GO terms | Fisher exact p value |
|---|---|---|---|
| Turquoise (n = 292) | Biological process | ncRNA processing | 2.07E-11 |
| rRNA metabolic process | 4.19E-10 | ||
| Endocrine pancreas development | 9.99E-09 | ||
| Molecular function | Nucleic acid binding | 1.8E-08 | |
| Structural constituent of ribosome | 1.28E-20 | ||
| Protein–DNA loading ATPase activity | 0.00153 | ||
| Cellular component | Cytosolic large ribosomal subunit | 2.66E-17 | |
| Nucleolus | 2.16E-10 | ||
| Intracellular | 1.58E-05 | ||
| Blue (n = 190) | Biological process | mRNA processing | 1.01E-44 |
| RNA splicing | 6.82E-41 | ||
| mRNA export from nucleus | 2.14E-16 | ||
| Molecular function | RNA binding | 1.97E-08 | |
| RS domain binding | 6.57E-06 | ||
| Nucleotide binding | 2.49E-05 | ||
| Cellular component | Nuclear speck | 3.55E-14 | |
| Spliceosomal complex | 1.29E-12 | ||
| Nucleus | 3.26E-15 | ||
| Brown (n = 61) | Biological process | Translation | 1.82E-15 |
| Molecular function | Structural constituent of ribosome | 1.28E-20 | |
| Translation regulator activity | 0.002275 | ||
| Cellular component | Mitochondrion | 9.67E-34 | |
| Ribosome | 1.91E-28 | ||
| Mitochondrial large ribosomal subunit | 1.51E-11 | ||
| Yellow (n = 46) | Biological process | Endocrine pancreas development | 9.99E-09 |
| Viral transcription | 9.99E-09 | ||
| Viral infectious cycle | 4.61E-08 | ||
| Molecular function | Structural constituent of ribosome | 1.28E-20 | |
| mRNA binding | 0.005748 | ||
| Cellular component | Cytosolic small ribosomal subunit | 1.78E-44 | |
| Ribosome | 1.91E-28 | ||
| Intracellular | 1.58E-05 | ||
| Green (n = 40) | Biological process | Spliceosomal snRNP assembly | 2.67E-20 |
| Regulation of cyclin-dependent protein kinase activity | 1.4E-06 | ||
| Spliceosome assembly | 5.74E-06 | ||
| Molecular function | snRNA binding | 6.37E-08 | |
| Cellular component | Small nuclear ribonucleoprotein complex | 5.26E-09 | |
| U12-type spliceosomal complex | 4.85E-08 | ||
| Cajal body | 1.05E-07 | ||
| Red (n = 20) | Biological process | Protein folding | 3.65E-06 |
| Response to abiotic stimulus | 2.37E-05 | ||
| Oxidation–reduction process | 0.000248 | ||
| Molecular function | Heat-shock protein binding | 7.28E-07 | |
| Purine ribonucleoside triphosphate binding | 3.21E-05 | ||
| Catalytic activity | 0.000225 | ||
| Cellular component | Microtubule | 0.000258 | |
| Membrane | 2.47E-05 | ||
| Intrinsic to membrane | 0.016518 | ||