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. 2018 Jul 18;38(29):6527–6545. doi: 10.1523/JNEUROSCI.0111-18.2018

Figure 5.

Figure 5.

CR2fH (administered 90 min after MCAO) is also protective in female mice and aged male mice (14 months old). a, CR2fH alone or in combination with rehabilitation significantly reduced neurological deficits in aged mice compared with vehicle; however, only CR2fH + rehabilitation was significantly better compared with rehabilitation only (p < 0.05). Two-way ANOVA, Bonferroni's correction, n = 7/group, *p < 0.05, **p < 0.01. b, Survival was significantly improved by CR2fH with or without rehabilitation in aged animals after MCAO. Experiments were terminated at day 10 due to loss of all vehicle controls. Log–rank (Mantel–Cox) test, n = 7/group, *p < 0.05. c, d, CR2fH improved neurological deficits and survival of adult female mice through 15 d after MCAO. c, Two-way ANOVA, Bonferroni's correction, n = 7/group, *p < 0.05, **p < 0.01. d, Log–rank (Mantel–Cox) test, n = 7/group. p = 0.057.