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Neutral drift-DNA shuffling landscapes from generations 1 to 8. The activities of the clones are plotted in descending order; the solid line shows the activity of the parent PaDa-I, and the dashed line represents the activity threshold, with purged clones within the blue region. Clones satisfying the activity threshold were considered neutral and were used as parental variants in subsequent rounds. m̄nt, average nucleotide mutations; m̄aa, average amino acid mutations.
