FIG 2.

Kinetics of wild-type CDV transmission to naive contact animals. Ferrets were infected intranasally with 2 × 10⁵ TCID₅₀ of the wild-type strain 5804PeH and then cohoused for consecutive 24-h periods immediately preceding the onset of clinical signs (A and B) or for consecutive 48-h periods during and after the onset of clinical signs (C and D). (A and C) The course of cell-associated viremia is shown as the log₁₀ of the virus titer per 10⁶ PBMCs for contact exposure periods of 24 h between days 4 and 7 (A) and for 48 h between days 6 and 11 (C). (B and D) Survival of infected and contact animals for contact exposure periods of 24 h between days 4 and 7 (B) and for 48 h between days 6 and 11 (D). The death of an animal is indicated by a step down on the curve, and the color-coded median survival for each group is indicated on the graphs. Each series in panels A and C represents one animal (n = 2 infected with 2 contacts per contact window). Symbols for panels A and B are indicated in panel B, and those for panels C and D are indicated in panel D. Days postinfection are indicated on the x axes of the graphs.