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. 2018 Jul 17;92(15):e00682-18. doi: 10.1128/JVI.00682-18

FIG 2.

FIG 2

Histopathological comparison of CNS tissues in EV71-inoculated monkeys. (A) Distribution of EV71-induced lesions. Postmortem CNS tissues at 10 dpi from monkeys inoculated with Isehara or C7/Osaka are shown. Filled triangles and circles indicate viral antigen-positive and neuronal damage, respectively. The gray areas show inflammation in the parenchyma and the meninges of the CNS. (B) Histopathological findings in spinal cord. Typical histopathological changes in the spinal cords of VP1-145E-inoculated groups are shown. Upper panels, histology of the lumbar part of the spinal cord of a monkey inoculated with Isehara-G (monkey 5215) and monkeys inoculated with Isehara-E (5217 and 5218) or C7-E (5257 and 5220), stained using H&E. Lower panels, higher magnifications of the boxes in the anterior horns in the upper panels. Prominent inflammatory infiltrations are indicated by arrowheads. Neuronal degenerations were seen in the anterior horns of the spinal cords within the lesion (arrows).