TABLE 1.
oHSV replication in GSC and ScGC lines
| Tumor type and patient specimen | Virus | Titer ratioa in: |
|
|---|---|---|---|
| GSCs | ScGCs | ||
| Primary | |||
| MGG4 | G207 | 0.7 | 9.7 |
| FΔ6 | 13.7 | 136.6 | |
| G47Δ | 32.7 | 415.7 | |
| MGG8 | G207 | 0.5 | 63.2 |
| FΔ6 | 154.9 | 34.5 | |
| G47Δ | 42.3 | 327.6 | |
| MGG18 | G207 | 3.5 | |
| FΔ6 | NT | NT | |
| G47Δ | 343 | ||
| MGG29 | G207 | 1.3 | 83.3 |
| FΔ6 | 25.8 | 83.3 | |
| G47Δ | 21.4 | 68.5 | |
| MGG75 | G207 | 0.5 | 8.2 |
| FΔ6 | 6.3 | 27.3 | |
| G47Δ | NT | NT | |
| Recurrent | |||
| MGG31 | G207 | 0.97 | 69.7 |
| FΔ6 | N/T | 612 | |
| G47Δ | 192 | 207 | |
| MGG70R | G207 | 0.4 | |
| FΔ6 | 29.7 | None | |
| G47Δ | 8.1 | ||
| MGG70RRb | G207 | 0.7 | |
| FΔ6 | 39.2 | None | |
| G47Δ | 7.0 | ||
| MGG123 | G207 | 0.7 | 99 |
| FΔ6 | 198.5 | NT | |
| G47Δ | 20.7 | 614 | |
a
The titer at 24 hpi was divided by the titer measured at 5 to 8 hpi. Cells were considered permissive if the ratio was at least 5 or represented half a log increase from the value at eclipse. Values were calculated from single experiments with technical triplicates. None, cells do not exist; NT, not tested.
b
MGG70RR was a re-recurrent tumor from MGG70R.