FIG 3.

FcRn-independent release of WW1 into the vagina and protection. (A) HPV16 PsV encoding a luciferase reporter plasmid infects FcRn knockout (KO) and wild-type (WT) C57BL/6 mice equivalently after vaginal challenge. (B) Passive transfer of WW1 (50 μg) protects both FcRn KO and WT mice against vaginal challenge with HPV16 PsV. (C) Higher concentrations of WW1 IgG are present in vaginal lavage samples obtained from WT and FcRn KO mice 12 h after N9 treatment than with cytobrush-induced disruption of the murine cervicovaginal epithelium.