TABLE 1.
Infection of vaccinees by neutralization-resistant SIVsmE660 A/K variants
| Group | Animal | TRIM-5α genotype | No. of exposures to infection | No. of Env proteins sequenced | % of Env proteins with nonconsensus A/K | No. of T/F variants | No. of T/F variants with A/K |
|---|---|---|---|---|---|---|---|
| TLR4+7 | T065 | R | 4 | 13 | 100 | 1 | 1 |
| TLR4+7 | T066 | M/S | 1 | 13 | 85 | 6 | 4 |
| TLR4+7 | T069 | M/S | 2 | 10 | 2 | ||
| TLR4+7 | T071 | M/S | 1 | 10 | 1 | ||
| TLR4+7 | T074 | M/S | 1 | 13 | 100 | 1 | 1 |
| TLR4+7 | T075 | R | 1 | 9 | 4 | ||
| TLR4+7 | T078 | M/S | 1 | 14 | 21 | 4 | 1 |
| TLR4+7 | T092 | R | 5 | 11 | 4 | ||
| TLR4+7 | T093 | R | 5 | 14 | 100 | 1 | 1 |
| TLR4+7 | T094 | M/S | 1 | 12 | 1 | ||
| TLR4+7 | T098 | R | 5 | 11 | 100 | 1 | 1 |
| TLR4+7 | T099 | M/S | 3 | 14 | 1 | ||
| TLR4+QS21 | T072 | M/S | 1 | 14 | 100 | 1 | 1 |
| TLR4+QS21 | T076 | R | 3 | 14 | 1 | ||
| TLR4+QS21 | T077 | M/S | 2 | 14 | 6 | ||
| TLR4+QS21 | T079 | M/S | 1 | 11 | 1 | ||
| TLR4+QS21 | T081 | R | 6 | 13 | 46 | 2 | 1 |
| TLR4+QS21 | T083 | M/S | 2 | 13 | 3 | ||
| TLR4+QS21 | T084 | M/S | 1 | 13 | 5 | ||
| TLR4+QS21 | T085 | M/S | 2 | 13 | 92 | 6 | 5 |
| TLR4+QS21 | T086 | M/S | 1 | 14 | 100 | 3 | 1 |
| TLR4+QS21 | T088 | R | 2 | 15 | 100 | 2 | 1 |
| TLR4+QS21 | T090 | R | 5 | 13 | 2 | ||
| TLR4+QS21 | T091 | R | 5 | 12 | 1 | ||
| Control/TLR4+7 | T080 | R | 4 | 14 | 2 | ||
| Control/TLR4+7 | T082 | M/S | 2 | 13 | 1 | ||
| Control/TLR4+7 | T095 | R | 1 | 11 | 7 | ||
| Control/TLR4+QS21 | T073 | M/S | 1 | 11 | 18 | 4 | 1 |
| Control/TLR4+QS21 | T087 | M/S | 5 | 11 | 4 | ||
| Control/TLR4+QS21 | T096 | M/S | 1 | 15 | 1 | ||
| Control naive | T067 | M/S | 1 | 16 | 3 | ||
| Control naive | T068 | R | 1 | 15 | 1 | ||
| Control naive | T070 | R | 1 | 10 | 20 | 7 | 1 |
| Control naive | T089 | M/S | 1 | 12 | 42 | 3 | 1 |
| Control naive | T097 | M/S | 1 | 11 | 3 | ||
| Control naive | T100 | R | 1 | 15 | 7 | 2 | 1 |