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. 2018 Jul 12;9:854. doi: 10.3389/fphys.2018.00854

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Copyright © 2018 Venglovecz, Pallagi, Kemény, Balázs, Balla, Becskeházi, Gál, Tóth, Zvara, Puskás, Borka, Sendler, Lerch, Mayerle, Kühn, Rakonczay and Hegyi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of AQP1 in patients with acute and chronic pancreatitis. Representative histological images show expression and localization of AQP1 in normal human pancreas (NP, A–C) acute necrotizing pancreatitis (ANP, D,E) and chronic pancreatitis (CP, F,G) samples. AQP1 immunoreactivity was detected in inter/intralobular and intercalated ducts, in the acinar and centroacinar cells of the normal pancreas. In contrast, expression of AQP1 strongly decreased in ANP and CP. id, interlobular duct; ic, intercalated duct; ca, centroacinar cells. (H) Intensity of diaminobenzidine staining was measured in pancreas samples by ImageJ software and expressed as percentage of total pancreatic area. ^∗p ≤ 0.05 vs. normal pancreas, n = 10–12.