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. 2018 Jun 28;9:700. doi: 10.3389/fphar.2018.00700

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Copyright © 2018 Ma, Zhou, Xu, Wang, Yang, Wang, Liu, Ran, Yan, Wu and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of SPN on IL-1β-induced chondrocyte-specific gene degradation and mRNA levels of cartilage matrix-degrading enzymes in rat chondrocytes. Chondrocytes were treated with different concentrations of SPN for 24 h, with or without IL-1β (5 ng/ml). The mRNA levels of chondrocyte-specific genes and matrix-degrading enzymes were evaluated by Real-Time PCR (n = 5 per group). Significance was calculated by one-way ANOVA with post hoc Tukey’s multiple comparisons test. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001 versus the IL-1+SPN (0 μM) group. ^##p < 0.01, ^###p < 0.001 versus the NC group.