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. 2018 Jul 16;7(1):1494482. doi: 10.1080/20013078.2018.1494482

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Validation of the MV-PGC assay in septic shock patients. A. Microvesicle-dependent plasmin generation capacities (MV-PGCs) at inclusion (H0) and at H24 of the surviving (S) and non-surviving (NS) septic shock patients compared to MV-PGC of MVs isolated from healthy donors (n = 24). The boxes and whiskers represent the medians and 25—75th percentiles of each population. B. Plasmin activator inhibitor type 1 (PAI-1) levels of the S and NS septic shock patients at inclusion (H0) and at H24. C. Impact of a range of PAI-1 concentrations (0.5–500 ng/mL) on MV-PGC of three samples of MVs with different levels of plasmin generation activity (high level: HL; medium level: ML; LL: low level). n = 3. D. Ratio of IMS-MV-PGC to PAI-1 concentration in SV and NSV (at H0 and H24). p ≤ 0.05 was considered significant. * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001.