Table 2.
Mean levels of enzymes detected in caries-free (CF), coronal caries (CC) and dentin caries (DC).
| Enzymes | CF (n = 4) | CF SEM | CC (n = 5) | CC SEM | DC (n = 6) | DC SEM |
|---|---|---|---|---|---|---|
| Alcohol dehydrogenase | 1.01E+ 01 | 8.35E+ 00 | 3.21E+ 00 | 1.45E+ 00 | 3.79E+ 00 | 9.54E-01 |
| 3-oxoacyl-[acyl-carrier-protein] reductase | 4.43E+ 00 | 5.82E-01 | 3.27E+ 00 | 1.19E+ 00 | 4.24E+ 00 | 1.74E+ 00 |
| L-threonine 3-dehydrogenase | 2.55E-02 | 1.59E-02 | 1.84E-02 | 1.15E-02 | 3.96E-02 | 1.47E-02 |
| All-trans-retinol dehydrogenase (NAD(+)) | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 1.20E-01 | 1.09E-01 |
| 2-deoxy-D-gluconate 3-dehydrogenase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 2.82E-02 | 2.82E-02 |
| 3-dehydro-L-gulonate 2-dehydrogenase | 6.00E-03 | 6.00E-03 | 1.40E-03 | 1.40E-03 | 3.72E-02 | 3.01E-02 |
| GDP-mannose 6-dehydrogenase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 8.68E-02 | 8.68E-02 |
| dTDP-4-dehydrorhamnose reductase | 4.57E-01 | 1.89E-01 | 2.76E-01 | 8.88E-02 | 1.49E+ 00 | 6.77E-01 |
| Mannitol 2-dehydrogenase (NADP(+)) | 9.45E-02 | 9.45E-02 | 0.00E+ 00 | 0.00E+ 00 | 3.38E-02 | 3.38E-02 |
| Sorbitol-6-phosphate 2-dehydrogenase | 2.18E+ 00 | 6.35E-01 | 1.34E+ 00 | 6.21E-01 | 1.16E+ 00 | 8.32E-01 |
| Ureidoglycolate dehydrogenase | 6.75E-03 | 6.75E-03 | 4.00E-03 | 4.00E-03 | 2.80E-02 | 2.65E-02 |
| 3-hydroxybutyryl-CoA dehydrogenase | 6.23E-02 | 5.77E-02 | 1.19E-01 | 6.96E-02 | 4.72E-01 | 2.47E-01 |
| 2-dehydropantoate 2-reductase | 1.04E+ 00 | 2.36E-01 | 3.74E-01 | 9.35E-02 | 7.78E-01 | 3.16E-01 |
| Mannitol-1-phosphate 5-dehydrogenase | 9.98E-02 | 5.39E-02 | 1.14E-01 | 6.64E-02 | 4.39E-01 | 1.24E-01 |
| D-xylose 1-dehydrogenase (NADP(+)) | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 5.82E-02 | 5.82E-02 |
| Inositol 2-dehydrogenase | 6.00E-03 | 6.00E-03 | 5.00E-03 | 5.00E-03 | 6.40E-01 | 5.56E-01 |
| Mannitol-1-phosphate 5-dehydrogenase | 9.98E-02 | 5.39E-02 | 1.14E-01 | 6.64E-02 | 4.39E-01 | 1.24E-01 |
| Morphine 6-dehydrogenase | 0.00E+ 00 | 0.00E+ 00 | 3.42E-02 | 3.42E-02 | 5.03E-01 | 4.17E-01 |
| 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming)bc | 1.01E-01 | 3.93E-02 | 1.58E-01 | 8.51E-02 | 2.31E+ 00 | 9.38E-01 |
| Serine 3-dehydrogenase (NADP(+))c | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 1.22E-01 | 4.33E-02 |
| Aryl-alcohol dehydrogenase (NADP(+)) | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 3.10E-01 | 2.01E-01 |
| Glycerol-3-phosphate dehydrogenase (NAD(P)(+))c | 4.07E+ 00 | 1.12E+ 00 | 2.76E+ 00 | 5.49E-01 | 5.24E+ 00 | 1.88E+ 00 |
| Choline dehydrogenasec | 3.50E-03 | 2.18E-03 | 1.92E-02 | 9.13E-03 | 1.08E-01 | 3.16E-02 |
| Phenylalanine 4-monooxygenase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 1.18E-01 | 9.24E-02 |
| Ferroxidase | 8.87E-01 | 3.36E-01 | 1.17E+ 00 | 6.54E-01 | 1.78E+ 00 | 4.83E-01 |
| Cob(II)yrinic acid a,c-diamide reductase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 4.96E-02 | 4.62E-02 |
| Bacterial non-heme ferritinc | 1.06E+ 00 | 5.80E-01 | 5.15E-01 | 1.48E-01 | 3.52E+ 00 | 9.58E-01 |
| 4-hydroxy-tetrahydrodipicolinate reductase | 6.22E+ 00 | 1.99E+ 00 | 6.63E+ 00 | 1.67E+ 00 | 5.67E+ 00 | 1.58E+ 00 |
| Succinylglutamate-semialdehyde dehydrogenase | 5.50E-03 | 5.50E-03 | 4.40E-03 | 4.40E-03 | 1.03E-01 | 4.80E-02 |
| 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 5.10E-02 | 2.46E-02 |
| 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 7.68E-01 | 4.19E-01 |
| D-proline reductase (dithiol)c | 6.95E-02 | 6.95E-02 | 0.00E+ 00 | 0.00E+ 00 | 4.38E-01 | 1.76E-01 |
| Betaine reductasebc | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 1.06E-01 | 4.84E-02 |
| Trans-2-enoyl-CoA reductase (NAD(+))b | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 1.57E-01 | 1.01E-01 |
| Dihydroorotate dehydrogenase (quinone)c | 2.70E-01 | 1.03E-01 | 2.87E-01 | 9.68E-02 | 9.19E-01 | 2.00E-01 |
| Glycine dehydrogenase (aminomethyl-transferring)c | 1.22E-01 | 7.75E-02 | 4.20E-02 | 2.58E-02 | 1.40E+ 00 | 8.34E-01 |
| Methylenetetrahydrofolate reductase (NAD(P)H)ab | 7.13E+ 00 | 8.30E-01 | 3.00E+ 00 | 7.71E-01 | 2.64E+ 00 | 6.15E-01 |
| FMN reductase (NADH) | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 2.04E-02 | 1.05E-02 |
| Carboxynorspermidine synthase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 6.36E-02 | 4.61E-02 |
| Nitrite reductase (NAD(P)H) | 4.23E-02 | 2.19E-02 | 1.40E-01 | 4.41E-02 | 2.05E-01 | 1.07E-01 |
| Peptide-methionine (R)-S-oxide reductasec | 5.60E-01 | 3.05E-01 | 1.28E-01 | 4.47E-02 | 8.28E-01 | 2.19E-01 |
| Phosphatidylethanolamine N-methyltransferasec | 8.75E-03 | 6.13E-03 | 0.00E+ 00 | 0.00E+ 00 | 2.38E-01 | 1.44E-01 |
| 16S rRNA (guanine(1207)-N(2))-methyltransferasebc | 8.75E-03 | 8.75E-03 | 1.28E-02 | 1.11E-02 | 2.18E-01 | 1.16E-01 |
| 16S rRNA (cytosine(967)-C(5))-methyltransferasebc | 7.50E-04 | 7.50E-04 | 1.00E-03 | 1.00E-03 | 4.40E-02 | 2.47E-02 |
| 16S rRNA (cytosine(1407)-C(5))-methyltransferase | 0.00E+ 00 | 0.00E+ 00 | 3.60E-03 | 2.20E-03 | 4.74E-02 | 3.23E-02 |
| 23S rRNA (adenine(2085)-N(6))-dimethyltransferase | 7.30E-02 | 5.02E-02 | 3.12E-01 | 2.91E-01 | 1.16E-02 | 7.28E-03 |
| 23S rRNA (uracil(747)-C(5))-methyltransferasebc | 5.25E-03 | 5.25E-03 | 1.80E-03 | 1.80E-03 | 2.17E-01 | 9.84E-02 |
| 23S rRNA (cytosine(1962)-C(5))-methyltransferasec | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 6.22E-02 | 3.14E-02 |
| Malonyl-[acyl-carrier protein] O-methyltransferase | 2.75E-03 | 2.75E-03 | 0.00E+ 00 | 0.00E+ 00 | 3.82E-02 | 1.85E-02 |
| 16S rRNA (cytidine(1402)-2’-O)-methyltransferase | 2.66E+ 00 | 4.41E-01 | 2.11E+ 00 | 5.15E-01 | 3.81E+ 00 | 1.59E+ 00 |
| tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase | 4.00E-03 | 4.00E-03 | 3.20E-03 | 3.20E-03 | 1.18E+ 00 | 5.76E-01 |
| Thymidylate synthase | 0.00E+ 00 | 0.00E+ 00 | 1.32E-02 | 1.32E-02 | 3.64E-01 | 1.59E-01 |
| 3-methyl-2-oxobutanoate hydroxymethyltransferasec | 3.60E-01 | 1.80E-01 | 4.34E-01 | 1.67E-01 | 1.68E+ 00 | 4.44E-01 |
| Diaminobutyrate acetyltransferasec | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 8.44E-02 | 4.57E-02 |
| Phosphinothricin acetyltransferase | 5.75E-03 | 5.75E-03 | 0.00E+ 00 | 0.00E+ 00 | 3.03E-01 | 1.44E-01 |
| Sulfoacetaldehyde acetyltransferase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 8.12E-02 | 4.64E-02 |
| Levansucraseb | 6.25E-03 | 5.01E-03 | 2.33E-01 | 1.72E-01 | 6.03E-01 | 2.69E-01 |
| 4-O-beta-D-mannosyl-D-glucose phosphorylasec | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 4.97E-01 | 2.43E-01 |
| Phosphatidylinositol alpha-mannosyltransferaseb | 5.75E-03 | 1.97E-03 | 7.58E-02 | 5.23E-02 | 3.48E-01 | 1.34E-01 |
| Uridine phosphorylasebc | 1.10E-01 | 4.26E-02 | 8.52E-02 | 5.84E-02 | 5.43E-01 | 2.14E-01 |
| Triphosphoribosyl-dephospho-CoA synthasec | 1.73E-01 | 8.60E-02 | 5.94E-02 | 1.82E-02 | 2.22E-01 | 4.83E-02 |
| Diaminobutyrate – 2-oxoglutarate transaminasec | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 5.72E-02 | 3.89E-02 |
| LL-diaminopimelate aminotransferasebc | 2.25E-03 | 2.25E-03 | 4.80E-03 | 3.34E-03 | 3.25E-01 | 1.18E-01 |
| Ribulokinasebc | 2.50E-03 | 2.50E-03 | 2.20E-03 | 1.74E-03 | 2.24E-01 | 1.33E-01 |
| Xylulokinasec | 1.13E-02 | 7.18E-03 | 9.20E-03 | 8.01E-03 | 8.02E-02 | 4.34E-02 |
| FAD:protein FMN transferasec | 4.40E-02 | 2.46E-02 | 7.80E-03 | 7.80E-03 | 1.25E-01 | 3.97E-02 |
| 3-deoxy-D-manno-octulosonic acid kinase | 9.25E-03 | 9.25E-03 | 6.40E-03 | 6.40E-03 | 2.45E-01 | 1.10E-01 |
| Glycerol kinaseb | 1.61E+ 00 | 2.19E-01 | 2.54E+ 00 | 1.08E+ 00 | 5.70E+ 00 | 1.02E+ 00 |
| Choline kinasebc | 6.61E+ 00 | 6.34E+ 00 | 3.57E-01 | 7.27E-02 | 2.98E-02 | 1.86E-02 |
| N-acetylglucosamine kinasec | 2.35E-02 | 1.07E-02 | 1.14E-02 | 9.53E-03 | 5.14E-01 | 3.08E-01 |
| Polyphosphate – glucose phosphotransferaseab | 4.08E-02 | 2.09E-02 | 6.76E-01 | 5.17E-01 | 1.05E+ 00 | 5.30E-01 |
| Inosine kinasec | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 2.46E-01 | 1.36E-01 |
| Glucosamine kinase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 7.32E-02 | 5.44E-02 |
| Acetylglutamate kinasebc | 8.51E-01 | 2.82E-01 | 6.37E-01 | 2.22E-01 | 2.50E+ 00 | 3.84E-01 |
| [Glutamate – ammonia-ligase] adenylyltransferaseb | 1.23E-01 | 5.67E-02 | 9.02E-02 | 2.82E-02 | 1.40E+ 00 | 7.54E-01 |
| Adenosylcobinamide-phosphate guanylyltransferasec | 4.25E-03 | 4.25E-03 | 0.00E+ 00 | 0.00E+ 00 | 9.92E-02 | 5.32E-02 |
| Diguanylate cyclase | 2.48E-02 | 7.32E-03 | 1.12E-02 | 1.12E-02 | 6.58E-02 | 2.51E-02 |
| Threonylcarbamoyladenylate synthasec | 4.96E-01 | 1.39E-01 | 3.61E-01 | 1.12E-01 | 8.56E-01 | 3.43E-01 |
| L-seryl-tRNA(Sec) selenium transferase | 4.75E-02 | 1.60E-02 | 2.88E-02 | 1.68E-02 | 4.28E-01 | 1.30E-01 |
| Protein-glutamate methylesterasebc | 0.00E+ 00 | 0.00E+ 00 | 9.40E-03 | 7.98E-03 | 4.64E-01 | 2.16E-01 |
| Nitrite reductase (NAD(P)H) | 4.23E-02 | 2.19E-02 | 1.40E-01 | 4.41E-02 | 2.05E-01 | 1.07E-01 |
| Peptide-methionine (R)-S-oxide reductasec | 5.60E-01 | 3.05E-01 | 1.28E-01 | 4.47E-02 | 8.28E-01 | 2.19E-01 |
| Phosphatidylethanolamine N-methyltransferase | 8.75E-03 | 6.13E-03 | 0.00E+ 00 | 0.00E+ 00 | 2.38E-01 | 1.44E-01 |
| 16S rRNA (guanine(1207)-N(2))-methyltransferase | 8.75E-03 | 8.75E-03 | 1.28E-02 | 1.11E-02 | 2.18E-01 | 1.16E-01 |
| 16S rRNA (cytosine(967)-C(5))-methyltransferase | 7.50E-04 | 7.50E-04 | 1.00E-03 | 1.00E-03 | 4.40E-02 | 2.47E-02 |
| 16S rRNA (cytosine(1407)-C(5))-methyltransferase | 0.00E+ 00 | 0.00E+ 00 | 3.60E-03 | 2.20E-03 | 4.74E-02 | 3.23E-02 |
| 23S rRNA (adenine(2085)-N(6))-dimethyltransferase | 7.30E-02 | 5.02E-02 | 3.12E-01 | 2.91E-01 | 1.16E-02 | 7.28E-03 |
| 23S rRNA (uracil(747)-C(5))-methyltransferase | 5.25E-03 | 5.25E-03 | 1.80E-03 | 1.80E-03 | 2.17E-01 | 9.84E-02 |
| 23S rRNA (cytosine(1962)-C(5))-methyltransferase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 6.22E-02 | 3.14E-02 |
| Malonyl-[acyl-carrier protein] O-methyltransferase | 2.75E-03 | 2.75E-03 | 0.00E+ 00 | 0.00E+ 00 | 3.82E-02 | 1.85E-02 |
| 16S rRNA (cytidine(1402)-2’-O)-methyltransferase | 2.66E+ 00 | 4.41E-01 | 2.11E+ 00 | 5.15E-01 | 3.81E+ 00 | 1.59E+ 00 |
| tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase | 4.00E-03 | 4.00E-03 | 3.20E-03 | 3.20E-03 | 1.18E+ 00 | 5.76E-01 |
| Thymidylate synthase | 0.00E+ 00 | 0.00E+ 00 | 1.32E-02 | 1.32E-02 | 3.64E-01 | 1.59E-01 |
| 3-methyl-2-oxobutanoate hydroxymethyltransferase | 3.60E-01 | 1.80E-01 | 4.34E-01 | 1.67E-01 | 1.68E+ 00 | 4.44E-01 |
| Diaminobutyrate acetyltransferase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 8.44E-02 | 4.57E-02 |
| Phosphinothricin acetyltransferase | 5.75E-03 | 5.75E-03 | 0.00E+ 00 | 0.00E+ 00 | 3.03E-01 | 1.44E-01 |
| Sulfoacetaldehyde acetyltransferase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 8.12E-02 | 4.64E-02 |
| Levansucrase | 6.25E-03 | 5.01E-03 | 2.33E-01 | 1.72E-01 | 6.03E-01 | 2.69E-01 |
| 4-O-beta-D-mannosyl-D-glucose phosphorylase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 4.97E-01 | 2.43E-01 |
| Phosphatidylinositol alpha-mannosyltransferase | 5.75E-03 | 1.97E-03 | 7.58E-02 | 5.23E-02 | 3.48E-01 | 1.34E-01 |
| Uridine phosphorylase | 1.10E-01 | 4.26E-02 | 8.52E-02 | 5.84E-02 | 5.43E-01 | 2.14E-01 |
| Triphosphoribosyl-dephospho-CoA synthase | 1.73E-01 | 8.60E-02 | 5.94E-02 | 1.82E-02 | 2.22E-01 | 4.83E-02 |
| Diaminobutyrate – 2-oxoglutarate transaminase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 5.72E-02 | 3.89E-02 |
| LL-diaminopimelate aminotransferase | 2.25E-03 | 2.25E-03 | 4.80E-03 | 3.34E-03 | 3.25E-01 | 1.18E-01 |
| Ribulokinase | 2.50E-03 | 2.50E-03 | 2.20E-03 | 1.74E-03 | 2.24E-01 | 1.33E-01 |
| Xylulokinase | 1.13E-02 | 7.18E-03 | 9.20E-03 | 8.01E-03 | 8.02E-02 | 4.34E-02 |
| FAD:protein FMN transferase | 4.40E-02 | 2.46E-02 | 7.80E-03 | 7.80E-03 | 1.25E-01 | 3.97E-02 |
| 3-deoxy-D-manno-octulosonic acid kinase | 9.25E-03 | 9.25E-03 | 6.40E-03 | 6.40E-03 | 2.45E-01 | 1.10E-01 |
| Glycerol kinase | 1.61E+ 00 | 2.19E-01 | 2.54E+ 00 | 1.08E+ 00 | 5.70E+ 00 | 1.02E+ 00 |
| Choline kinase | 6.61E+ 00 | 6.34E+ 00 | 3.57E-01 | 7.27E-02 | 2.98E-02 | 1.86E-02 |
| N-acetylglucosamine kinase | 2.35E-02 | 1.07E-02 | 1.14E-02 | 9.53E-03 | 5.14E-01 | 3.08E-01 |
| Polyphosphate – glucose phosphotransferase | 4.08E-02 | 2.09E-02 | 6.76E-01 | 5.17E-01 | 1.05E+ 00 | 5.30E-01 |
| Inosine kinase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 2.46E-01 | 1.36E-01 |
| Glucosamine kinase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 7.32E-02 | 5.44E-02 |
| Acetylglutamate kinase | 8.51E-01 | 2.82E-01 | 6.37E-01 | 2.22E-01 | 2.50E+ 00 | 3.84E-01 |
| [Glutamate – ammonia-ligase] adenylyltransferase | 1.23E-01 | 5.67E-02 | 9.02E-02 | 2.82E-02 | 1.40E+ 00 | 7.54E-01 |
| Adenosylcobinamide-phosphate guanylyltransferase | 4.25E-03 | 4.25E-03 | 0.00E+ 00 | 0.00E+ 00 | 9.92E-02 | 5.32E-02 |
| Diguanylate cyclase | 2.48E-02 | 7.32E-03 | 1.12E-02 | 1.12E-02 | 6.58E-02 | 2.51E-02 |
| Threonylcarbamoyladenylate synthase | 4.96E-01 | 1.39E-01 | 3.61E-01 | 1.12E-01 | 8.56E-01 | 3.43E-01 |
| Alkaline phosphatase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 3.11E-01 | 1.41E-01 |
| 2’,3’-cyclic-nucleotide 2’-phosphodiesterase | 1.63E-01 | 6.62E-02 | 1.81E-01 | 7.27E-02 | 3.83E-01 | 2.92E-01 |
| Beta-glucuronidaseb | 1.13E-02 | 6.42E-03 | 3.26E-02 | 1.59E-02 | 1.01E-01 | 2.61E-02 |
| Beta-N-acetylhexosaminidase | 1.56E+ 00 | 4.68E-01 | 1.80E+ 00 | 4.68E-01 | 3.12E+ 00 | 1.06E+ 00 |
| Levanasec | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 2.13E-01 | 1.08E-01 |
| Arabinogalactan endo-beta-1,4-galactanase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 6.43E-01 | 3.24E-01 |
| Glucan 1,6-alpha-isomaltosidase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 4.11E-01 | 2.06E-01 |
| Uracil-DNA glycosylasec | 2.16E+ 00 | 9.31E-01 | 1.21E+ 00 | 2.87E-01 | 4.62E+ 00 | 1.52E+ 00 |
| PepB aminopeptidasebc | 2.80E-02 | 2.24E-02 | 1.14E-02 | 6.23E-03 | 3.02E-01 | 9.27E-02 |
| Gamma-D-glutamyl-meso-diaminopimelate peptidasec | 8.78E-02 | 5.96E-02 | 1.32E-01 | 7.75E-02 | 0.00E+ 00 | 0.00E+ 00 |
| Prolyl oligopeptidase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 2.68E-02 | 1.64E-02 |
| Repressor LexAc | 1.22E+ 00 | 9.76E-02 | 1.07E+ 00 | 4.27E-01 | 4.25E+ 00 | 1.38E+ 00 |
| Gingipain R | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 1.54E-01 | 1.10E-01 |
| Microbial collagenase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 6.62E-02 | 3.70E-02 |
| Mycothiol S-conjugate amidaseb | 3.25E-02 | 1.63E-02 | 1.22E-01 | 4.89E-02 | 3.00E-01 | 1.23E-01 |
| Ureasebc | 2.35E-01 | 1.19E-01 | 3.57E-01 | 8.34E-02 | 3.39E+ 00 | 1.07E+ 00 |
| Arginine deiminase | 3.78E+ 00 | 1.51E+ 00 | 3.02E+ 00 | 1.27E+ 00 | 8.11E+ 00 | 3.76E+ 00 |
| Adenosine deaminasebc | 1.69E-01 | 4.30E-02 | 3.15E-01 | 8.53E-02 | 8.10E-01 | 2.08E-01 |
| NAD(+) diphosphatasec | 1.03E-02 | 4.87E-03 | 0.00E+ 00 | 0.00E+ 00 | 2.36E-01 | 1.16E-01 |
| Guanosine-5’-triphosphate,3’-diphosphate diphosphatasec | 7.75E-03 | 4.48E-03 | 8.00E-03 | 8.00E-03 | 1.61E-01 | 5.63E-02 |
| Glycerol-3-phosphate-transporting ATPase | 0.00E+ 00 | 0.00E+ 00 | 2.60E-03 | 2.60E-03 | 1.92E-01 | 1.65E-01 |
| Cu(+) exporting ATPasec | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 5.46E-02 | 3.30E-02 |
| b Phosphoribosylaminoimidazole carboxylaseb | 2.75E-02 | 1.05E-02 | 7.18E-02 | 2.72E-02 | 1.74E-01 | 2.98E-02 |
| Phosphoenolpyruvate carboxykinase (GTP)c | 3.11E-01 | 1.48E-01 | 4.43E-01 | 1.67E-01 | 2.22E+ 00 | 4.87E-01 |
| 2-oxoglutarate decarboxylasebc | 3.90E-02 | 2.54E-02 | 4.94E-02 | 2.79E-02 | 3.64E-01 | 8.45E-02 |
| 3-dehydro-L-gulonate-6-phosphate decarboxylase | 6.25E-03 | 6.25E-03 | 2.20E-03 | 2.20E-03 | 1.51E-01 | 7.97E-02 |
| Aminodeoxychorismate lyase | 0.00E+ 00 | 0.00E+ 00 | 6.20E-03 | 4.32E-03 | 1.00E-01 | 4.01E-02 |
| Tryptophanasebc | 9.55E-02 | 3.74E-02 | 6.14E-02 | 1.92E-02 | 8.42E-01 | 3.11E-01 |
| Ectoine synthase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 8.40E-02 | 6.57E-02 |
| L(+)-tartrate dehydratasec | 1.60E-01 | 1.34E-01 | 7.16E-02 | 2.46E-02 | 9.19E-01 | 3.71E-01 |
| Myo-inosose-2 dehydratase | 0.00E+ 00 | 0.00E+ 00 | 5.00E-03 | 5.00E-03 | 6.22E-01 | 3.49E-01 |
| GDP-mannose 4,6-dehydratasec | 3.00E-01 | 2.88E-01 | 3.74E-02 | 3.06E-02 | 1.13E+ 00 | 4.85E-01 |
| 1-aminocyclopropane-1-carboxylate synthase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 6.60E-02 | 6.60E-02 |
| Cellobiose epimerase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 4.85E-01 | 2.25E-01 |
| N-acylglucosamine-6-phosphate 2-epimerase | 2.40E+ 00 | 1.33E+ 00 | 1.87E+ 00 | 8.83E-01 | 1.99E+ 00 | 9.10E-01 |
| L-rhamnose isomerasec | 6.23E-02 | 3.44E-02 | 1.82E-02 | 7.00E-03 | 1.28E+ 00 | 6.14E-01 |
| Xylose isomerasebc | 2.38E-02 | 8.63E-03 | 5.86E-02 | 4.50E-02 | 1.08E+ 00 | 6.12E-01 |
| 23S rRNA pseudouridine(2457) synthase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 1.52E-01 | 1.31E-01 |
| 23S rRNA pseudouridine (955/2504/2580) synthase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 7.30E-02 | 4.22E-02 |
| RNA pseudouridine(65) synthase | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 0.00E+ 00 | 8.66E-02 | 6.99E-02 |
| RNA pseudouridine(32) synthasebc | 3.25E-03 | 3.25E-03 | 2.20E-03 | 2.20E-03 | 1.69E-01 | 9.64E-02 |
| 23S rRNA pseudouridine (746) synthasebc | 3.25E-03 | 3.25E-03 | 2.20E-03 | 2.20E-03 | 1.69E-01 | 9.64E-02 |
| Acetate – CoA ligase | 0.00E+ 00 | 0.00E+ 00 | 1.47E-01 | 1.47E-01 | 3.80E-02 | 2.47E-02 |
| Long-chain-fatty-acid – CoA ligasebc | 1.57E-01 | 7.10E-02 | 1.46E-01 | 6.37E-02 | 6.88E-01 | 1.93E-01 |
| Asparagine synthase (glutamine-hydrolyzing) | 0.00E+ 00 | 0.00E+ 00 | 5.40E-03 | 4.47E-03 | 2.07E-01 | 1.07E-01 |
P ≤ 0.05 a = CF vs CC, b = CF vs DC, c = CC vs DC