Table 2.
Comparison of Association of Individual SNPs and Gene Score with Obesity
| Gene | SNP/GS | OR | p-value |
|---|---|---|---|
| GRB14 | rs3923113 | 0.903 | 0.598 |
| ST6GAL1 | rs16861329 | 0.586 | 0.007 |
| VPS26A | rs1802295 | 1.366 | 0.087 |
| AP3S2 | rs2028299 | 1.351 | 0.094 |
| HNF4A | rs4812829 | 1.429 | 0.047 |
| HMG20A | rs7178572 | 1.149 | 0.373 |
| FABP2 | Ala54Thr | 1.379 | 0.045 |
| LEP | G2548A | 1.560 | 0.006 |
| LEPR | Gln223Arg | 1.379 | 0.045 |
| FTO | rs1121980 | 1.346 | 0.089 |
| Gene Score | 1.175 | 0.0001 | |
The OR for the individual SNPs and the p-values indicate a marginal or no association with the outcome, however, when a gene score is used, the association with obesity becomes significant