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. 2018 Jul 18;10:96. doi: 10.1186/s13148-018-0528-6

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — A scatterplot with a regression line and 95% confidence intervals showing associations between epigenetic age acceleration and salivary cortisol upon awakening in 11.0–13.2-year-old adolescents. Epigenetic age acceleration is calculated as the residual from a linear regression where DNA methylation age is regressed on chronological age and adjusted for six cell types. Numbers showing percent increase in salivary cortisol upon awakening per 1 year increase in epigenetic age acceleration and 95% confidence intervals are derived from generalized linear models with Gaussian reference distribution and adjusted for three multidimensional scaling components from genome-wide data, adolescent’s sex, and time upon awakening (model 1); and model 1 plus birth weight, gestational age, parity, delivery mode, maternal age and body mass index at delivery, maternal smoking, alcohol and glycyrrhizin in licorice use during pregnancy, and highest achieved education of either parent in adolescence follow-up (model 2); and model 2 plus body-mass-index-for-age SD score in adolescence (model 3)