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. 2018 Jul 18;10:96. doi: 10.1186/s13148-018-0528-6

Table 1.

Characteristics of the sample

Child characteristics at birth: N Mean/N SD/% Range
 Sex (boys) 239 116 48.5
 Length of gestation (weeks) 239 40.0 1.3 35.6–42.4
 Birth weight (g) 239 3571 472 1890–4995
 Birth length (cm) 239 50.3 1.9 43.0–55.0
 Birth order 239
  First 136 56.9
  Second or later 103 43.1
Child characteristics in adolescence:
 Chronological age (years) 239 12.4 0.5 11.1–13.2
 DNA methylation age (years) 239 12.1 3.1 5.4–22.5
 Weight (kg) 238 48.7 10.8 23.2–91.1
 Weight-for-age (SD) 238 0.3 1.0 − 3.6 – 3.0
 Height (cm) 238 156.2 7.5 134.5–177.0
 Height-for-age (SD) 238 0.2 1.0 − 2.7 – 2.5
 Body mass index (kg/m2) 238 19.8 3.44 12.8–34.5
 Body-mass-index-for-age (SD) 238 0.3 1.0 − 3.1 – 2.7
 Target height (SD) 238 173.4 7.6 153.9–191.7
 Mid-parental target height (SD) minus height-for-age (SD) 238 0.5 1.0 − 1.9 – 3.5
Tanner Staging Questionnaire
  Pubic hair development 233
   I 50 21.5
   II 83 35.6
   III 71 30.5
   IV 29 12.4
  Breast/genitalia development 234
   I 18 7.7
   II 81 34.6
   III 83 35.5
   IV 52 22.2
Pubertal development scale 236
 No development 139 58.9
 Development barely begun 74 31.4
 Development definitely under way 23 9.7
Diurnal salivary cortisol
 ln(upon awakening) 218 1.7 0.6 − 1.7 – 3.6
 ln(awakening response) 218 0.4 0.7 − 0.9 – 6.3
 ln(Nadir) 218 − 0.9 0.9 − 2.3 – 1.8
 ln(response to dexamethasone suppression test) 213 0.4 0.8 −v5.2 – 3.0
Psychiatric problems (> 82nd percentile borderline clinically significant problems) 222
 Total behavior problems 38 17.1
 Internalizing problems 18 8.1
 Externalizing problems 25 11.3
Intelligence quotient, estimated (M = 100; SD = 15)*
 General 235 105.8 14.8 57–140
 Verbal 236 111.4 17.2 57–153
 Performance 237 100.9 19.7 42–141
Maternal characteristics:
 Age at delivery (years) 239 30.4 4.4 20.0–43.0
 Weight at delivery (kg) 237 63.4 9.9 45.0–98.0
 Height (cm) 239 166.8 5.5 151.0–180.0
 Body mass index at delivery (kg/m2) 237 22.8 3.5 16.5–36.0
 Mode of delivery 239
  Vaginal 214 89.5
  Cesarean 25 10.5
Alcohol consumption during pregnancy 239
  No 199 83.3
  Yes 40 16.7
Smoking during pregnancy 239
  No 217 90.8
  Yes 22 9.2
Consumption of glycyrrhizin in licorice during pregnancy 239
  Low (0–249 mg/week) 174 72.8
  Medium (250–499 mg/week) 33 13.8
  High (≥ 500 mg/week) 32 13.4
Age at menarche (years) 228
  Mothers of girls 120 12.69 1.39 9.0–16.0
  Mothers of boys 108 12.70 1.19 10.0–16.0
Paternal/parental characteristics:
 Paternal height (cm) 236 180.07 6.38 157.00–200.00
 Highest educational level of either parent at child’s adolescence follow-up 239
  Secondary or less 25 10.5
  Vocational 59 24.7
  University degree 155 64.9

Note: *3, 3, and 7 children had estimated general, verbal, and performance intelligence quotient below 70 because of difficulties in visual processing