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. 2018 Jul 18;19:223. doi: 10.1186/s12891-018-2156-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Distal Femoral Metaphysis μCT results. Representative regions of interest of trabecular bone for Adult (left) and Aged (right) femurs at baseline. Adult rats exhibited greater BV/TV, Tb.N, and reduced Tb.Sp than Aged rats. 14 days of hindlimb unloading resulted in significant loss of trabecular bone in Adult rats, but no significant decrease in Aged rats. By day 3 of reloading, Adult rats had recovered trabecular bone volume, while Aged rats exhibited continued loss of bone. Brackets indicate significant differences between groups (p < 0.05). Asterisks (*) indicate a main effect of age in a parameter between Adult and Aged animals (p < 0.05)