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. 2018 Jul 18;19:223. doi: 10.1186/s12891-018-2156-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Mid Femoral Diaphysis μCT Results. Representative samples of regions of interest in Adult (left) and Aged (right) femurs. Aged rats had lower average cortical thickness than Adult rats, but greater bone area and total cross-sectional area. Neither age group exhibited changes in cortical structure due to hindlimb unloading or reloading. Brackets indicate significant differences between groups (p < 0.05). Asterisks (*) indicate a main effect of age in a parameter between Adult and Aged animals (p < 0.05)