Table 1.

Schedule of assessments

	Screening	Baseline (Month 0)	Day 3 Post-Infusion	Month 3	Month 6	Month 12	Day 3 Post-Infusion	Month 18	Month 24
Informed consent	x
Clinical examination	x
Knee x-ray	x
Bloods	x				x*
Knee MRI	x				x				x
Randomisation		x
Clinic measures
Leg strength		x			x	x			x
Height and weight		x			x				x
First void fasting urine		x*			x*
Infusion		x				x
Questionnaire measures
Demographics (sex, date of birth)	x
Knee VAS	x	x		x	x	x		x	x
Knee WOMAC		x		x	x	x		x	x
Medication use	x			x	x	x		x	x
Knee surgery	x			x	x	x		x	x
Knee joint injection					x	x		x	x
Safety (adverse events)		x	x	x	x	x	x	x	x
Acute phase reactions			x				x
Hand VAS		x		x	x	x		x	x
Back VAS		x		x	x	x		x	x
AQoL-4D		x			x				x
Overall change in pain and function									x
Treatment guessing									x

*Only being performed at the Hobart, Melbourne and Sydney study sites

MRI magnetic resonance imaging, VAS visual analogue scale, WOMAC Western Ontario and McMasters Universities Osteoarthritis Index, AQoL-4D The Assessment of Quality of Life