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. 2018 Jul 18;18:747. doi: 10.1186/s12885-018-4665-2

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Study scheme. Patients are stratified into three functional groups by comprehensive geriatric assessment and receive different intensity treatments. After the first cycle, CGA is repeated and patients are attributed to their definitive treatment groups. The primary end point (decrease of five points or less in Barthels ADL) is assessed by the second CGA