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. 2018 May 5;7(7):551–558. doi: 10.1002/sctm.17-0200

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© 2018 The Authors stemcellstranslationalmedicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Increased numbers of labeled MSCs in lungs following transfer. Numbers of transferred tdTomato⁺ MSCs in lungs were analyzed by flow cytometry. Recipient mice received elastase instillation 21 days prior to MSC transfer, and ATRA (PPE + MSC/ATRA) or vehicle (PPE + MSC/vehicle) were administered following the transfer until the last experimental days. A group of mice received saline instillation 21 days prior to MSC transfer and ATRA treatment (saline + MSC/ATRA). (A): Ratio of tdTomato⁺ cells to total lung cells. (B): Estimated absolute numbers of tdTomato⁺ cells per lung. n = 6 in each group. *, p < .05 versus PPE + MSC/vehicle and saline + MSC/ATRA. Abbreviations: ATRA, all‐trans retinoic acid; MSCs, mesenchymal stem cells; PPE, porcine pancreatic elastase.