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. 2018 Jul 18;9:196. doi: 10.1186/s13287-018-0946-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — a Effect of cisplatin and its combination with bone-marrow derived mesenchymal stem cells (BM-MSCs) on mean seminiferous tubule diameter. Data were presented as mean ± SD ^*Significant difference from the normal group at p < 0.05. ^#Significant difference from cisplatin group at p < 0.05. b Cross-sections of the testes with hematoxylin and eosin staining (H&E ×400) showing regular seminiferous tubules (295 μm in diameter) with normal spermatogenesis, Sertoli cells, and mature spermatids in the normal group (b1); irregular seminiferous tubules (187 μm in diameter) with Sertoli cells only and maturation arrest. No evidence of spermatids in the cisplatin group (b2); regular seminiferous tubules (269 μm in diameter) with Sertoli cells, more germ cell layers, more spermatids near to that of normal in the stem cell group (b3)