Fig. 4.

Reversible dysregulated expression of MET and EMT proteins on CRC reprogramming and re-differentiation. a Representative western blots of the EMT proteins, vimentin (VIM) & Snail1 (SNAI1) and the MET proteins E-cadherin (CDH1) and occludin (OCLN) in the parental CRC, the iPC and the respective differentiation-derived post-iPC clones. In the E-cadherin blots, arrowheads indicate the anticipated protein size (see text). b Quantification of changes of EMT and MET protein levels from three independent experiments. Data presented as mean ± SEM. P values were derived by comparing iPC vs parental cells and post-iPC vs iPC cells; *p < 0.05; **p < 0.01