Table 1.
Top ten differentially up- or down-regulated miRNAs in reprogrammed CRC-iPCs
| miRNA | Chromosome | miRNA familya | Log2FCb |
|---|---|---|---|
| A. Up-regulated | |||
| miR-125b-5p | 11q24.1 | mir-10 | 8.88 |
| miR-199a-3p | 19p13.2 | mir-199 | 7.04 |
| miR-125a-3p | 19q13.41 | mir-10 | 6.89 |
| miR-4734 | 17 | NA | 6.36 |
| miR-6789-5p | 19 | NA | 6.24 |
| miR-4417 | 1 | NA | 6.21 |
| miR-150-3p | 19q13.33 | mir-150 | 5.86 |
| miR-6723-5p | 1 | NA | 5.77 |
| miR-3934-5p | 6 | mir-3934 | 5.71 |
| miR-1181 | 19 | mir-1181 | 5.67 |
| B. Down-regulated | |||
| miR-192-5p | 11q13.1 | mir-192 | −6.17 |
| miR-338-3p | 17q25.3 | mir-338 | −4.84 |
| miR-455-3p | 9q32 | mir-455 | −4.63 |
| miR-362-5p | Xp11.23 | mir-362 | −4.42 |
| miR-6741-3p | 1 | NA | −4.37 |
| miR-6743-3p | 11 | NA | −4.34 |
| miR-552-3p | 1p34.3 | mir-552 | −4.15 |
| miR-6782-5p | 17 | NA | −4.05 |
| miR-4254 | 1 | NA | −4.02 |
| miR-4725-5p | 17 | NA | −3.99 |
aBased on miRBase database ver. 21; Log2 Fold change (FC) is relative to the parental CRC cells. Only log2FC > 2.0 or < − 2.0 and p < 0.05 are shown. NA not annotated