Table 2.
Clinical, anthropometric and biochemical characteristics of study population
| Characteristics | 2nd line ART (n = 100) | 1st line ART (n = 100) | ART naïve (n = 100) | Control (n = 300) | ||||
|---|---|---|---|---|---|---|---|---|
| Age group (year) | 20–40 | 40–60 | 20–40 | 40–60 | 20–40 | 40–60 | 20–40 | 40–60 |
| HIV diagnosed time in months (mean ± SD) | 53.8 | 78.5 | 68.0 | 80.4 | 22.7 | 34.9 | NA | NA |
| Time on ART in months (mean ± SD) | 51.3 | 76.8 | 63.6 | 65.7 | NA | NA | NA | NA |
| Cholesterol/HDL ratio ± SD | 7.4 ± 3.2** | 7.9 ± 3.4** | 6.1 ± 2.4** | 7.3 ± 3.9** | 3.8 ± 1.0** | 3.7 ± 0.9** | 3.4 ± 0.7 | 3.7 ± 0.7 |
| Blood Pressure [mean of systolic and diastolic BP (mmHg) ± SD] | 109 ± 8.5** | 111 ± 9.2** | 106 ± 7.6** | 111 ± 8.7** | 102 ± 5.8** | 103 ± 7.2** | 101 ± 3.5 | 101 ± 3.6 |
| Waist circumference (cm ± SD) M-male/F-female | M-96.3 F-91.36 |
M-98.95 F-91.67 |
M-86.60 F-88 |
M-93.98 F-91.67 |
M-83.11 F-75.96 |
M-85.09 F-79.50 |
M-81.84 F-79 |
M-81.96 F-79.45 |
| Insulin resistance (HOMA) ± SD | 6.62 ± 5.29** | 8.15 ± 7.07** | 4.83 ± 3.21** | 6.05 ± 4.14** | 2.48 ± 1.05** | 3.05 ± 1.56** | 1.80 ± 0.81 | 1.91 ± 0.87 |
| 8-OHdG (ng/ml) ± SD | 2.79 ± 0.95** | 3.27 ± 0.99** | 2.50 ± 0.91** | 3.13 ± 0.92** | 1.81 ± 0.66** | 1.95 ± 0.56** | 1.07 ± 0.25 | 1.30 ± 0.32 |
HIV detected time in months, time on ART in months, cholesterol/HDL ratio, blood pressure (means of systolic and diastolic blood pressure), waist circumference, insulin resistance (Homeostasis model assessments), DNA damage marker 8-hydroxy-2-deoxyguanosine (8-OHdG). Values are mean ± SD of subjects. The data were analyzed by one-way ANOVA. ** P < 0.01 significant when compared to control