Table 1.

The expression and functions of chemokine receptors in mouse DC subtypes

DC subtypes	Chemokine GPCR	Major functions	References
cDC	CCR1	Recruitment into the lungs during allergic reactions	105
	CCR2	Central tolerance	106
	CCR2, CCR6	Migration to inflamed tissue (immature)	107
	CCR2, CX3CR1	Positioning in the lung	21
	CCR4	Emigration of cutaneous DCs to the lymph nodes	39
	CCR6, CCR1	Recruitment to Peyer’s patches	108
	CCR7	Migration to lymph nodes	10
	CX3CR1	Migration to lymph vessels, LEC transmigration	37
	CXCR4	Bone marrow retention (DC precursors)	21
		Cutaneous DC transmigration across LEC	38
	CXCR5	Th2 induction	109
		Recruitment to Peyer’s patches	110
	XCR1	CD8 + T-cell priming and activation	111
		Central tolerance induction	112
		Intestinal immune homeostasis	113
pDC	CCR2	Homeostatic trafficking	114
	CCR2, CCR5	Bone marrow egression	115
	CCR6, CCR10	Recruitment to inflamed epithelia	116
	CCR9	Homing to the small intestine	117
		Oral tolerance	118
		Central tolerance	119
	CXCR4	Progenitor differentiation in bone marrow niches	120
	CXCR4, CCR7, and CXCR3	Spleen- and HEV-mediated lymph node entry	50,121,122