Table 1.

Classical chemoattractant GPCRs and ligands

Receptor	Expression	Ligands	Functions
FPR1	Myeloid cells, lymphocytes, tumor cells	Bacteria- and host-derived peptides	Leukocyte chemotaxis and activation, tumor growth, invasion, angiogenesis
FPR2	Myeloid cells, tumor cells	Bacteria- and host-derived peptides	Leukocyte chemotaxis and activation, antitumor defense, tumor invasion
FPR3	Monocytes, dendritic cells, tumor cells	Synthetic and host-derived peptides	Monocyte and DC chemotaxis and activation, tumor invasion
PAFR	Macrophages, granule leucocytes, various tissue cells, tumor cells	PAF	Leukocyte chemotaxis and activation, tumor growth and metastasis; angiogenesis
C5aR	Basophils, dendritic cells, mast cells, various nonimmune cells, tumor cells	C5a	Leukocyte chemotaxis and activation, tumor metastasis; oppositing function in angiogenesis
LTB4R (BLT1)	Neutrophils, macrophages, T-lymphocytes, tumor cells	LTB4	Leukocyte chemotaxis and activation, tumor growth
LTB4R (BLT2)	Most human tissues cells, leukocytes, tumor cells	LTB4	Leukocyte chemotaxis and activation, tumor growth and metastasis
CMKLR1 (ChemR23)	Mainly in myeloid cells	Chemerin, C15, RvE1	Migration of macrophages, DCs and PDCs

Abbreviations: CMKLR1, chemokine-like receptor 1; C5aR, activated complement component 5 receptor (C5aR), LTB4R, leukotriene B4 receptor; DC, dendritic cell; FPR, formyl peptide receptor; GPCR, G-protein coupled receptor; PAFR, platelet-activating factor receptor; PDC, plasmacytoid DC; RvE1, Resolvin E1.