Table 5.
Chemokine GPCRs in inflammation and immunity
| Diseases | Chemokine receptors | References |
|---|---|---|
| Autoimmune disorder | ||
| Psoriasis | CCR1, CXCR1, CXCR2, CXCR3 | 56, 57, 58 |
| RA | CCR1, CCR2, CXCR1, CXCR2, CXCR3 | 56, 57, 58, 59, 60 |
| MS | CCR1, CCR2, CXCR3 | 56, 57, 60, 61 |
| Pulmonary diseases | ||
| Asthma | CCR2, CCR3, CCR4, CCR5, CCR6, CCR8, CXCR4, CX3CR1 | 62, 63 |
| COPD | CXCR1, CXCR2 | 64, 65 |
| Metabolic and vascular disease | ||
| Atherosclerosis | CCR2, CX3CR1 | 66, 67 |
| Diabetes | CCR2, CX3CR1 | 56, 68, 69 |
| Obesity | CCR2, CCR5, CXCR2 | 56, 68 |
| Transplant rejection | CCR1, CCR2, CCR5, CXCR3 | 70, 71 |
| Infectious diseases | ||
| HIV | CCR5, CXCR4 | 56, 72, 73 |
| Sepsis | CXCR1, CXCR2 | 74, 75 |
| IBD | CCR9 | 56, 76, 77 |
Abbreviations: CCR, C-C cchemokine motif receptor; COPD, chronic obstructive pulmonary disease; CXCL, C-X-C cchemokine motif ligand; CXCR, C-X-C cchemokine motif receptor; IBD, inflammatory bowel disease; GPCR, G-protein coupled receptor; HIV, human immunodeficiency virus; MS, multiple sclerosis; RA, rheumatoid arthritis.