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. 2017 Mar 13;15(4):367–376. doi: 10.1038/cmi.2016.72

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© CSI and USTC 2017

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, and provide a link to the Creative Commons license. You do not have permission under this license to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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TC-PTP^IEC−KO mice are more susceptible to DSS-induced colitis. (a) Percentage of body weight loss and gain of 12 age-matched TC-PTP^fl/fl mice (WT, DSS) and TC-PTP^IEC−KO mice (IEC-KO, DSS) after 10 days of 5% DSS treatment. In parallel, nine control TC-PTP^fl/fl mice (WT) and five TC-PTP^IEC−KO mice (IEC-KO) were given regular water. There was a statistically significant difference between the groups as determined by one-way ANOVA (F(3,36)=14.51, P<0.0001). (b) Colon length in millimeters (mm). There was a statistically significant difference between the IEC-KO DSS treated and untreated groups as determined by one-way ANOVA (F(3,36)=6.23, P=0.0016). (c) Histopathological score of controls and TC-PTP^IEC−KO mice after DSS treatment based on inflammatory cell infiltration and epithelial injury. Error bars indicate mean±s.e.m. *P<0.05. (d) Representative H&E staining of colonic tissues from control and TC-PTP^IEC−KO mice following DSS treatment demonstrating the epithelial damage. n=12. Bar, 50 μM. ANOVA, analysis of variance; DSS, dextran sulphate sodium; TC-PTP, T-cell protein tyrosine phosphatase; WT, wild type.