Table 3.

The correlation and regression coefficient of estimated changes and baseline values with estimated change of different factors during study periods, obtained within linear mixed model.

Estimated	Estimated changes per year*				Baseline values
Change per year*		α-synuclein	P-tau	T-tau	Aβ42	α-synuclein	P-tau	T-tau	Aβ42
α-synuclein	r		0.015	0.092	0.096	−0.310	−0.036	−0.125	0.042
	B		0.309	27.400	0.429	−0.020	−0.211	−0.306	0.022
	P		0.871	0.335	0.314	0.001	0.708	0.190	0.663
P-tau	r	0.015		−0.220	0.387	0.129	0.030	0.228	−0.068
	B	0.001		−3.286	0.087	0.000	0.009	0.028	−0.002
	P	0.871		0.020	0.000	0.175	0.750	0.016	0.476
T–tau	r	0.092	−0.220		−0.159	−0.762	−0.399	−0.983	−0.193
	B	0.000	−0.015		−0.002	0.000	−0.008	−0.008	0.000
	P	0.335	0.020		0.094	0.000	0.000	0.000	0.041
Aβ1-42	r	0.096	0.387	−0.159		0.297	−0.052	0.127	0.635
	B	0.021	1.731	−10.599		0.004	−0.068	0.070	0.075
	P	0.314	0.000	0.094		0.002	0.587	0.182	0.000

r, Correlation coefficient.

B, Linear regression coefficient.

^*Estimated changes were calculated for each subject based on the regression coefficient of each subject within a linear mixed model.

The correlations were assessed between different biomarkers in the study. One single biomarker could not have a correlationship with itself and they were marked black.