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. 2018 Jul 16;11:4087–4095. doi: 10.2147/OTT.S171043

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© 2018 Li et al. This work is published and licensed by Dove Medical Press Limited

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Effects of miR-19b on cell proliferation, migration, and invasion in MCF-7 and MDA-MB-231 cells.

Notes: (A) In the two cell lines, expression of miR-19b was significantly increased by miR-19b mimic but was decreased by miR-19b inhibitor compared with the corresponding NCs (^***P<0.001). (B) Cell proliferation was enhanced by overexpression of miR-19b but was suppressed by knockdown of miR-19b in both MCF-7 and MDA-MB-231 cells (^*P<0.05 and ^**P<0.01). (C) The results of migration analysis for MCF-7 and MDA-MB-231 cells. (D) The results of invasion assay for MCF-7 and MDA-MB-231 cells. (E, F) Overexpression of miR-19b by miR-19b mimic could promote the cell migration and invasion, but the downregulated miR-19b expression could inhibit the cell migration and invasion (^*P<0.05, ^**P<0.01, and ^***P<0.001).

Abbreviations: miR-19b, microRNA-19b; NC, negative control.

Effects of miR-19b on cell proliferation, migration, and invasion in MCF-7 and MDA-MB-231 cells.

Notes: (A) In the two cell lines, expression of miR-19b was significantly increased by miR-19b mimic but was decreased by miR-19b inhibitor compared with the corresponding NCs (^***P<0.001). (B) Cell proliferation was enhanced by overexpression of miR-19b but was suppressed by knockdown of miR-19b in both MCF-7 and MDA-MB-231 cells (^*P<0.05 and ^**P<0.01). (C) The results of migration analysis for MCF-7 and MDA-MB-231 cells. (D) The results of invasion assay for MCF-7 and MDA-MB-231 cells. (E, F) Overexpression of miR-19b by miR-19b mimic could promote the cell migration and invasion, but the downregulated miR-19b expression could inhibit the cell migration and invasion (^*P<0.05, ^**P<0.01, and ^***P<0.001).

Abbreviations: miR-19b, microRNA-19b; NC, negative control.