Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Combined nimotuzumab and celecoxib cooperatively inhibits cytoplasmic and nuclear EGFR signaling pathways in CNE2 cell line. CNE2 cells were incubated with N50 or C25 or the combination for 48 hours. Cytoplasmic and nuclear extracts were harvested for Western blot analysis. (A) Cytoplasmic levels of EGFR, p-EGFR, p-ERK1/2, p-STAT3, p-AKT and COX-2. (B) Nuclear levels of EGFR and PCNA.
