Table 2.
Day 3 AKI, Demographics and Outcomes
| Variable | No AKIS N=1222 (76.8) |
AKIS N=368 (23.1) |
P Value |
|---|---|---|---|
|
| |||
| Male | 683 (55.9) | 199 (54.1) | 0.54 |
|
| |||
| Age in months | 49.1 (16.3, 127.9) | 75.5 (17.9, 165.7) | 0.002 |
|
| |||
| BSA m2 | 0.67 (0.46, 1.18) | 0.84 (0.47, 1.36) | 0.005 |
|
| |||
| Diagnosis Group* | |||
| Shock | 343 (28.1) | 129 (35.1) | 0.01 |
| CV | 70 (5.7) | 29 (7.9) | 0.13 |
| Respiratory | 581 (47.5) | 167 (45.4) | 0.47 |
| Trauma | 237 (19.4) | 90 (24.5) | 0.04 |
| CNS | 263 (21.5) | 64 (17.4) | 0.09 |
| Pain Management or Sedation | 41 (3.4) | 12 (3.3) | 0.93 |
|
| |||
| History of Transplantation | 62 (5.1) | 50 (13.6) | <0.001 |
|
| |||
| Severity of Illness Score | |||
| PRISM-3 | 5 (3, 8) | 7 (3, 12) | 0.03 |
| PIM-2 | 3 (1, 4) | 3 (1, 5) | 0.09 |
| PELOD | 11 (1, 12) | 11 (1, 12) | 0.52 |
|
| |||
| RA+ | 165 (13.5) | 121 (32.9) | <0.001 |
|
| |||
| Day 0 KDIGO AKI | |||
| No AKI | 1040 (85.1) | 248 (67.4) | <0.001 |
| Stage 1 | 140 (11.5) | 34 (9.2) | 0.23 |
| Stage 2 | 55 (4.5) | 37 (10.0) | <0.001 |
| Stage 3 | 23 (1.9) | 49 (13.3) | <0.001 |
| All-stage AKI | 218 (17.8) | 120 (32.6) | <0.001 |
| Severe AKI | 78 (6.4) | 86 (23.4) | <0.001 |
|
| |||
| Ventricular Assist Device | 3 (0.2) | 1 (0.3) | 0.93 |
|
| |||
| ECMO | 14 (1.1) | 9 (2.4) | 0.07 |
|
| |||
| Renal Replacement Therapy | 18 (1.5) | 40 (10.9) | <0.001 |
|
| |||
| MV Duration | 1 (0, 6) | 1 (0, 5) | 0.57 |
|
| |||
| ICU LOS | 5 (4, 9) | 4 (3, 7.8) | <0.001 |
|
| |||
| Mortality | 53 (4.3) | 28 (7.6) | 0.01 |
Categorical Variables expressed as n (% of cohort)
Continuous Variables expressed as medians with interquartile ranges
Day 3 AKI = KDIGO ≥ Stage 2
*
More than one diagnosis group is possible
N = population, BSA = body surface area, IQR = interquartile range, CV = cardiovascular, CNS = central nervous system, PRISM-3 = Pediatric Risk of Mortality 3, PIM-2 =Pediatric Index of Mortality 2, PELOD = Pediatric Logistic Organ Dysfunction, KDIGO - Kidney Diseases Improving Global Outcomes, AKI = acute kidney injury, RA+ = renal angina positive, ICU = intensive care unit, ECMO = extracorporeal membrane oxygenation, MV = mechanical ventilation, LOS = length of stay