Table 3.
Creatinine Elevation versus Renal Angina Fulfillment
| Variable | SCr>Base N = 696 (43.8) |
RA+ N = 286 (17.9) |
P value |
|---|---|---|---|
|
| |||
| Male | 386 (55.4) | 144 (50.3) | 0.14 |
|
| |||
| Age in months | 45.6 (11.4, 143.8) | 49.9 (11.5,155.0) | 0.43 |
|
| |||
| Primary Diagnosis Group* | |||
| Shock | 226 (32.5) | 135 (47.2) | <0.001 |
| CV | 46 (6.6) | 20 (6.9) | 0.82 |
| Trauma | 133 (19.1) | 64 (22.4) | 0.25 |
| CNS | 134 (19.3) | 39 (13.6) | 0.04 |
|
| |||
| Severity of Illness Score | |||
| PRISM-3 | 5 (3,9) | 7(2,14) | 0.09 |
| PIM-2 | 2.5 (1,5) | 3 (1,6) | 0.16 |
| PELOD | 11 (1,12) | 11 (1,19) | 0.13 |
|
| |||
| History of Transplantation | 81 (11.6) | 57 (19.9) | <0.001 |
|
| |||
| Day 3 AKI Incidence | |||
| No AKI | 404 (58.0) | 121 (42.3) | <0.001 |
| Stage 1 | 109 (15.7) | 44 (15.4) | 0.91 |
| Stage 2 | 61 (8.7) | 41 (14.3) | 0.009 |
| Stage 3 | 122 (17.5) | 80 (27.9) | <0.001 |
| All-stage AKI (AKIA) | 292 (41.9) | 165 (57.7) | <0.001 |
| Severe AKI (AKIS) | 184 (26.4) | 121 (42.3) | <0.001 |
| Relative Risk (AKIS)# | 1.61 (1.33–1.93) | <0.001 | |
|
| |||
| AKIS Prediction | |||
| Sensitivity | 80 (56–94) | 67 (59–75) | |
| Specificity | 70 (62–77) | 87 (85–88) | |
| Positive Predictive Value | 25 (20–32) | 31(28–35) | |
| Negative Predictive Value | 96 (92–99) | 97 (96–97) | |
| Positive Likelihood Ratio | 2.6 (1.9–3.6) | 5.0 (4.2–5.9) | |
| AUC-ROC | 0.86 (0.82–0.89) | 0.83 (0.79–0.86) | |
|
| |||
| RRT Use | 41 (5.9) | 36 (12.6) | <0.001 |
|
| |||
| MV Duration | 1 (0,6) | 3.5 (0,9) | <0.001 |
|
| |||
| ECMO | 14 (2.0) | 9 (3.8) | 0.29 |
|
| |||
| ICU LOS | 5 (3,9) | 5 (3,10) | 0.96 |
|
| |||
| Mortality | 44 (6.3) | 32 (11.2) | 0.009 |
Categorical Variables expressed as n (% of cohort)
Continuous Variables expressed as medians with interquartile ranges
More than one diagnosis group is possible
Z-statistic: 5.07
SCr>Base = Serum creatinine greater than baseline creatinine, RA+ = renal angina fulfillment, AKI = acute kidney injury, BSA = body surface area, CV = cardiovascular, CNS = central nervous system, PRISM-III = Pediatric Risk of Mortality Score III, PIM-2 = Pediatric Index of Mortality-2, PELOD = Pediatric Logistic Organ Dysfunction, AUC-ROC = area under curve receiver operating characteristic, MV duration = mechanical ventilation duration, ICU = intensive care unit, ECMO = extracorporeal membrane oxygenation, RRT=Renal replacement therapy, LOS = length of stay