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Schematic of the glucose-responsive insulin delivery system utilizing H2O2 and pH cascade-responsive NC-loading MN-array patch. a) Formation of Ins-NCs and GOx-NCs and mechanism of glucose-responsive insulin release. b) Schematic of H2O2-triggered charge reduction of the polymer. c) Schematic of the NC-containing MN-array patch with a CAT sheath structure for in vivo insulin delivery. Insulin release is triggered under a hyperglycemic state.
