. Author manuscript; available in PMC: 2018 Jul 19.

Published in final edited form as: Curr Opin Biotechnol. 2017 Mar 11;48:28–32. doi: 10.1016/j.copbio.2017.03.001

Table 1.

Summary of recently developed bioresponsive transcutaneous patches

Stimulus	Materials	Model therapeutics	Ref.
pH	PVP, pH-sensitive PLGA nanoparticles	Alexa488 and Cy5	[23]
	Pyridine modified silicon, N-trimethyl chitosan	Ovalbumin	[24,26]
	Metal, polydopamine, heparin, and albumin	DNA	[25]
Glucose	HA, hypoxia-sensitive vesicles	Insulin	[20^•,30^•]
	HA, H₂O₂-sensitive polymersomes	Insulin	[31^•]
	HA, hypoxia and H₂O₂ dual-sensitive polymersomes	Insulin	[32]
	HA, pH-sensitive dextran nanoparticles	anti-PD-1	[33]
Enzyme	1-MT conjugated HA	1-MT and anti-PD-1	[37]
Enzyme	Heparin conjugated HA	Heparin	[38]