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. 2018 Feb 8;1:11. doi: 10.1038/s42003-017-0011-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Schematic of the artificial antiviral miRNA. a Target genes. b Expression cassettes. Based on mariner transposon system, the ubiquitous and midgut-specific induction promoters were used for expressing the downstream synthetic miRNAs. AeCPA/PUb promoter, Ae. aegypti carboxypeptidase A/PolyUbiquitin promoter; 4miR:DENV-3, anti DENV-3 miRNA cluster for four anti-DENV-3 miRNAs; 6miR:CHIKV, anti CHIKV miRNA cluster for six anti-CHIKV miRNAs; 10miR:DENV-3+CHIKV, anti DENV-3/CHIKV miRNA cluster for four for DENV-3 and six for CHIKV