Table 4.
Baseline variables – responder vs nonresponder
| Variable | Responder (n=10) | Nonresponder (n=10) | p-value |
|---|---|---|---|
| Age (years), mean (SD) | 52.0 (7.7) | 51.5 (5.3) | 0.878 |
| Number of females (% of group) | 7 (70%) | 8 (80%) | 1.0 |
| MS duration (years) | 12.1 (6.4) | 17.2 (10.3) | 0.200 |
| EDSS (score), median (IQR) | 6.25 (6.0–6.5) | 6.50 (6.0–7.0) | 0.236 |
| DMD use (% of group) | 4 (40%) | 3 (30%) | 1.0 |
| FSS (score) | 5.85 (5.17) | 5.13 (4.10) | 0.205 |
| TUG time – total (s) | 22.2 (14.9–26.7) | 53.2 (26.1–81.8) | 0.186 |
| TUG time – stand (s) | 2.5 (1.2–3.1) | 3.2 (1.9-5.1) | 0.449 |
| TUG time – sit (s) | 3.3 (3.2–4.5) | 7.8 (5.4–15.7) | 0.075* |
| TUG time – turn (s) | 3.3 (2.8–4.3) | 9.1 (5.3–15.0) | 0.089* |
| TUG time – first 10 feet (s) | 5.2 (4.3–8.9) | 14.7 (6.6–23.8) | 0.076* |
| TUG time – second 10 feet (s) | 5.2 (3.2–6.9) | 13.8 (8.1–23.1) | 0.059* |
| TUG gait – long step (cm) | 46.97 (11.13) | 36.50 (11.01) | 0.048** |
| TUG gait – short step (cm) | 46.09 (34.13–50.01) | 27.10 (22.40–38.26) | 0.112 |
| TUG gait – step duration (s) | 0.84 (0.67–1.10) | 1.40 (0.91–2.86) | 0.069* |
| TUG gait – stride duration (s) | 1.64 (1.34–1.84) | 2.84 (2.17–5.76) | 0.041** |
| TUG gait – double support duration (s) | 0.23 (0.11–0.38) | 0.77 (0.33–1.31) | 0.121 |
| T25FW speed (cm/s) | 13.1 (9.7–25.8) | 41.0 (16.5–98.5) | 0.104 |
| Berg balance test (score) | 42.0 (35.0–46.0) | 24.5 (4.0–41.0) | 0.148 |
Notes:
*
p<0.1;
**
p<0.05. Data presented as mean (SD), n (%) or median (IQR).
Abbreviations: MS, multiple sclerosis; EDSS, expanded disability status scale; IQR, interquartile range; DMD, disease modifying drug; FSS, fatigue severity scale; SD, standard deviation; TUG, timed up and go; T25FW, timed 25-foot walk.