Table 4. Perturbations of the circuits whose functionality is controlled by miR-449a that affect the probabilities of the bistable dynamics in the model.
Probabilities were calculated using a Monte Carlo algorithm with 1000 runs in GINsim. E1 represents GoF and KO represents LoF of the corresponding element of the circuit.
| Circuits | miR-449a | ||
|---|---|---|---|
| Negative | Perturbations | E1 | |
| Phenotype | Probability | ||
| ATM/p53-MAIN/Wip1 | KO/E1/KO | G2/M or Apoptosis | 25%, 75% |
| E1/E1/KO | G2/M or Apoptosis | 25%, 75% | |
| KO/E1/E1 | G2/M or Apoptosis | 37%, 63% | |
| E1/E1/E1 | G2/M or Apoptosis | 37%, 63% | |
| p53-MAIN/Mdm2 | E1/KO | G2/M or Apoptosis | 21%, 79% |
| E2F1/Sirt-1 | KO/KO | G2/M or Apoptosis | 31%, 69% |
| E1/KO | G2/M or Apoptosis | 36%, 64% | |
| Positive | |||
| RB/Mdm2 | E1/KO | G2/M or Apoptosis | 29%, 71% |
| p53-MAIN/14-3-3s | E1/KO | G2/M or Apoptosis | 22%, 78% |
| E1/E1 | G2/M or Apoptosis | 25%, 75% | |