Table 3. Associations of allelic profiles (or allelic profile lineage‡) and mutations causing macrolide resistance.
| Allelic profile (Allelic profile lineage) |
Macrolide sensitive | Macrolide resistant (A2058G) | p value |
|---|---|---|---|
| 1.3.1* | 1 | 68 | |
| 1.1.1 | 6 | 10 | p = 0.0001 |
| 1.3.1 lineage* | 1 | 73 | |
| 1.1.1 lineage | 8 | 14 | p = 0.000019 |
| 1.3.1 lineage* | 1 | 73 | |
| other samples | 12 | 25 | p = 0.0000047 |
‡allelic profile lineage is a group of allelic profiles related to each other based on sequence similarity (as illustrated in Fig 4, panel C). The names of the lineages were derived from the most prevalent allelic profile in the lineage.
*in 1 sample of allelic profile 1.3.1, the 23S rDNA locus PCR product was unsuccessfully amplified.