Table 4.
Pathway analysis listing Reactome pathways significant at False Discovery Rate (FDR) <0.15 and p<0.01.
| PATHWAY_ID | GENESET_LABEL | SIZE | p-value | FDR |
|---|---|---|---|---|
| REACT_150203 | IRS-related events triggered by IGF1R | 82 | 0.001592357 | 0.140394097 |
| REACT_18352 | Eicosanoid ligand-binding receptors | 15 | 0.002004008 | 0.140394097 |
| REACT_163919 | Inactivation, recovery and regulation of the phototransduction cascade | 32 | 0.002094241 | 0.140394097 |
| REACT_19238 | CD28 dependent Vav1 pathway | 11 | 0.002132196 | 0.140394097 |
| REACT_12056 | NGF signalling via TRKA from the plasma membrane | 199 | 0.002314815 | 0.140394097 |
| REACT_21310 | Phospholipase C-mediated cascade | 55 | 0.003120125 | 0.140394097 |
| REACT_19405 | CTLA4 inhibitory signaling | 22 | 0.003243243 | 0.140394097 |
| REACT_22384 | Netrin mediated repulsion signals | 10 | 0.003333333 | 0.140394097 |
| REACT_23765 | Reduction of cytosolic Ca++ levels | 10 | 0.004052685 | 0.140394097 |
| REACT_163722 | The phototransduction cascade | 33 | 0.004188482 | 0.140394097 |
| REACT_12519 | PECAM1 interactions | 11 | 0.004324324 | 0.140394097 |
| REACT_21272 | Downstream signaling of activated FGFR | 142 | 0.004514673 | 0.140394097 |
| REACT_17025 | Downstream signal transduction | 154 | 0.004514673 | 0.140394097 |
| REACT_120736 | Signaling by FGFR in disease | 167 | 0.004524887 | 0.140394097 |
| REACT_9000 | Calmodulin induced events | 28 | 0.004733728 | 0.140394097 |
| REACT_9053 | CaM pathway | 28 | 0.004733728 | 0.140394097 |
| REACT_13477 | Transmission across Chemical Synapses | 195 | 0.004807692 | 0.140394097 |
| REACT_111064 | DAG and IP3 signaling | 33 | 0.004987531 | 0.140394097 |
| REACT_12478 | EGFR interacts with phospholipase C-gamma | 35 | 0.004987531 | 0.140394097 |
| REACT_115720 | PLCG1 events in ERBB2 signaling | 36 | 0.004987531 | 0.140394097 |
| REACT_21346 | Activation of Ca-permeable Kainate Receptor | 12 | 0.004995005 | 0.140394097 |
| REACT_21322 | Ionotropic activity of Kainate Receptors | 12 | 0.004995005 | 0.140394097 |
| REACT_15526 | G-protein mediated events | 45 | 0.005284016 | 0.140394097 |
| REACT_15307 | Ca-dependent events | 30 | 0.00591716 | 0.140394097 |
| REACT_1946 | PKA activation in glucagon signalling | 17 | 0.006012024 | 0.140394097 |
| REACT_15530 | PKA activation | 16 | 0.006012024 | 0.140394097 |
| REACT_1665 | Glucagon signaling in metabolic regulation | 33 | 0.006012024 | 0.140394097 |
| REACT_9470 | Signaling by FGFR | 152 | 0.006772009 | 0.140394097 |
| REACT_147814 | DAP12 signaling | 158 | 0.006802721 | 0.140394097 |
| REACT_147694 | DAP12 interactions | 171 | 0.006802721 | 0.140394097 |
| REACT_115755 | Signaling by ERBB2 | 154 | 0.006880734 | 0.140394097 |
| REACT_15306 | Cytosolic tRNA aminoacylation | 25 | 0.006993007 | 0.140394097 |
| REACT_15497 | PKA-mediated phosphorylation of CREB | 17 | 0.007014028 | 0.140394097 |
| REACT_25149 | Ion transport by P-type ATPases | 40 | 0.007246377 | 0.140394097 |
| REACT_121315 | Glycosaminoglycan metabolism | 122 | 0.007389163 | 0.140394097 |
| REACT_147739 | MPS IX - Natowicz syndrome | 122 | 0.007389163 | 0.140394097 |
| REACT_147853 | Mucopolysaccharidoses | 122 | 0.007389163 | 0.140394097 |
| REACT_147788 | MPS IIIB - Sanfilippo syndrome B | 122 | 0.007389163 | 0.140394097 |
| REACT_147719 | MPS VI - Maroteaux-Lamy syndrome | 122 | 0.007389163 | 0.140394097 |
| REACT_147825 | MPS IV - Morquio syndrome A | 122 | 0.007389163 | 0.140394097 |
| REACT_147860 | MPS IIIC - Sanfilippo syndrome C | 122 | 0.007389163 | 0.140394097 |
| REACT_147759 | MPS VII - Sly syndrome | 122 | 0.007389163 | 0.140394097 |
| REACT_147734 | MPS II - Hunter syndrome | 122 | 0.007389163 | 0.140394097 |
| REACT_147857 | MPS I - Hurler syndrome | 122 | 0.007389163 | 0.140394097 |
| REACT_147749 | MPS IIID - Sanfilippo syndrome D | 122 | 0.007389163 | 0.140394097 |
| REACT_147753 | MPS IIIA - Sanfilippo syndrome A | 122 | 0.007389163 | 0.140394097 |
| REACT_147798 | MPS IV - Morquio syndrome B | 122 | 0.007389163 | 0.140394097 |
| REACT_12079 | PLC-gamma1 signalling | 35 | 0.007604563 | 0.141476557 |
| REACT_1195 | Insulin receptor signalling cascade | 85 | 0.007961783 | 0.142554162 |
| REACT_121206 | Chondroitin sulfate/dermatan sulfate metabolism | 50 | 0.007981756 | 0.142554162 |
| REACT_19183 | CD28 co-stimulation | 29 | 0.008695652 | 0.149889707 |
| REACT_21247 | FRS2-mediated cascade | 37 | 0.00872818 | 0.149889707 |