Skip to main content
. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Pain. 2018 Aug;159(8):1494–1507. doi: 10.1097/j.pain.0000000000001232

Figure 6. Medial Prefrontal Cortex Activity in Response to Reward No-Loss Outcomes.

Figure 6

(A) Raw time course plots of mPFC ROI activity (group means and standard error) split by outcomes (hits or misses) for −$5 anticipation trials. The period of reward outcome (out) fMRI BOLD response is estimated to correspond to 10–14 seconds during the raw time course plots [presentation of outcome and post-outcome during TRs 4 and 5 (6–10 seconds) plus 4 seconds to account for hemodynamic response function (HRF) delay]. (B) Contrast (NVLout)) activation maps of mPFC ROI during reward outcome (hits versus misses) to −$5 anticipation trials (p < 0.05, uncorrected). (C) Contrast (NVLout) beta values extracted from the ROI for mPFC reward outcome activity. (D, E, F, G) Correlations between mPFC NVLout extracted beta values and trait anxiety (STAI Trait), negative affect (PANAS subscale), mood disturbance (POMS), and fatigue (PROMIS Fatigue) for both groups (solid black lines) with 95% confidence intervals (gray shading), and in patients only (dashed gray line in trait anxiety plot, confidence intervals not shown). All beta values shown as 10−3. STAI, State Trait Anxiety Inventory; PANAS, Positive and Negative Affect Schedule; POMS, Profile of Mood States.