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. 2018 Jul 19;8:10929. doi: 10.1038/s41598-018-29086-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Summary of significant age-associated splicing events. (A) Number of significant age-associated splicing events across 48 tissues. (B) Number of significant up-regulated (increased with aging) and down-regulated (decreased with aging) exon skipping events across 48 tissues in gray and yellow color respectively. (C) Hierarchical biclustering of top age-associated exon skipping events across individuals, based on PSI value of each event; the columns represent events and the rows represent 83 individuals with age information; blue indicates higher PSI and red indicates lower PSI. (D) Box plot of age distributions of the three identified clusters of individuals. (E) Scatter plot illustrating an up-regulated cassette exon event (COL6A3: chr2:238285987–238287279:238287878–238289558) in Uterus. (F) Scatter plot illustrating a down-regulated cassette exon event (NFE2L1:chr17:46133960–46134394:46134483–46134706) in Uterus.